Neuroimmunology: Immune signals packaged in the brain
Nature Reviews Immunology 17, 278 (2017).
doi:10.1038/nri.2017.43
Author: Lucy Bird
Astrocyte-shed extracellular vesicles provide long-distance messages to promote peripheral immune responses following brain injury. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 26, 2017 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Cytokines: Oncostatin M – a new target in IBD?
Nature Reviews Immunology 17, 280 (2017).
doi:10.1038/nri.2017.45
Author: Yvonne Bordon
Oncostatin M promotes intestinal inflammation and can predict responsiveness to anti-TNF therapy in patients with inflammatory bowel diseases. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 26, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Insect Immunity: Mechanism of adaptive immunity found in the fruitfly
Nature Reviews Immunology 17, 278 (2017).
doi:10.1038/nri.2017.44
Author: Alexandra Flemming
Haemocytes in Drosophila melanogaster facilitate antiviral immunity by amplifying and systemically disseminating RNA interference-mediated responses via exosome-like vesicles. Moreover, they allow for immune memory, akin to adaptive immune responses in mammals. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 26, 2017 Category: Allergy & Immunology Authors: Alexandra Flemming Tags: Research Highlight Source Type: research
Neuroimmunology: Immune signals packaged in the brain
Nature Reviews Immunology 17, 278 (2017).
doi:10.1038/nri.2017.43
Author: Lucy Bird
Astrocyte-shed extracellular vesicles provide long-distance messages to promote peripheral immune responses following brain injury. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 26, 2017 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
The immunopathology of sepsis and potential therapeutic targets
Nature Reviews Immunology 17, 407 (2017).
doi:10.1038/nri.2017.36
Authors: Tom van der Poll, Frank L. van de Veerdonk, Brendon P. Scicluna & Mihai G. Netea
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. In sepsis, the immune response that is initiated by an invading pathogen fails to return to homeostasis, thus culminating in a pathological syndrome that is characterized by (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 24, 2017 Category: Allergy & Immunology Authors: Tom van der Poll Frank L. van de Veerdonk Brendon P. Scicluna Mihai G. Netea Tags: Review Source Type: research
Monocyte differentiation and antigen-presenting functions
Nature Reviews Immunology 17, 349 (2017).
doi:10.1038/nri.2017.28
Authors: Claudia V. Jakubzick, Gwendalyn J. Randolph & Peter M. Henson
Monocytes develop in the bone marrow and represent the primary type of mononuclear phagocyte found in the blood. They were long thought of as a source for tissue macrophages, but recent studies indicate more complex roles for monocytes, both within the circulation and after their (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 24, 2017 Category: Allergy & Immunology Authors: Claudia V. Jakubzick Gwendalyn J. Randolph Peter M. Henson Tags: Review Source Type: research
Microbiota: Diet can protect against type 1 diabetes
Nature Reviews Immunology 17, 279 (2017).
doi:10.1038/nri.2017.40
Author: Elisabeth Kugelberg
Microbial metabolites can protect mice from diabetes by decreasing the frequency of autoreactive T cells and promoting the frequency of regulatory T cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 19, 2017 Category: Allergy & Immunology Authors: Elisabeth Kugelberg Tags: Research Highlight Source Type: research
Altered B cell signalling in autoimmunity
Nature Reviews Immunology 17, 421 (2017).
doi:10.1038/nri.2017.24
Authors: David J. Rawlings, Genita Metzler, Michelle Wray-Dutra & Shaun W. Jackson
Recent work has provided new insights into how altered B cell-intrinsic signals — through the B cell receptor (BCR) and key co-receptors — function together to promote the pathogenesis of autoimmunity. These combined signals affect B cells at two distinct stages: first, in the selection (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 10, 2017 Category: Allergy & Immunology Authors: David J. Rawlings Genita Metzler Michelle Wray-Dutra Shaun W. Jackson Tags: Review Source Type: research
Mitochondrial DNA in innate immune responses and inflammatory pathology
Nature Reviews Immunology 17, 363 (2017).
doi:10.1038/nri.2017.21
Authors: A. Phillip West & Gerald S. Shadel
Mitochondrial DNA (mtDNA) — which is well known for its role in oxidative phosphorylation and maternally inherited mitochondrial diseases — is increasingly recognized as an agonist of the innate immune system that influences antimicrobial responses and inflammatory pathology. On entering the cytoplasm, extracellular space or (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 10, 2017 Category: Allergy & Immunology Authors: A. Phillip West Gerald S. Shadel Tags: Review Source Type: research
Emil von Behring: translational medicine at the dawn of immunology
Nature Reviews Immunology 17, 341 (2017).
doi:10.1038/nri.2017.37
Author: Stefan H. E. Kaufmann
On 31st March 1917, Emil von Behring passed away. Why is this event so important for immunologists a century later? (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 10, 2017 Category: Allergy & Immunology Authors: Stefan H. E. Kaufmann Tags: Comment Source Type: research
Immunometabolism: Stress-induced macrophage polarization
Nature Reviews Immunology 17, 277 (2017).
doi:10.1038/nri.2017.41
Author: Kirsty Minton
Activation of the IRE1α-mediated stress response pathway in adipose tissue macrophages suppresses M2 polarization. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 10, 2017 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Mechanisms of central tolerance for B cells
Nature Reviews Immunology 17, 281 (2017).
doi:10.1038/nri.2017.19
Author: David Nemazee
Immune tolerance hinders the potentially destructive responses of lymphocytes to host tissues. Tolerance is regulated at the stage of immature B cell development (central tolerance) by clonal deletion, involving apoptosis, and by receptor editing, which reprogrammes the specificity of B cells through secondary recombination of (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 3, 2017 Category: Allergy & Immunology Authors: David Nemazee Tags: Review Source Type: research
Finding order in chaos
Nature Reviews Immunology 17, 280 (2017).
doi:10.1038/nri.2017.20
Author: Linda Sherman
Linda Sherman describes a 1991 study by Hans-Georg Rammensee and colleagues that defines allele-specific motifs required for the binding of peptides to MHC molecules. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - April 3, 2017 Category: Allergy & Immunology Authors: Linda Sherman Tags: Research Highlight Source Type: research
