Altered B cell signalling in autoimmunity

Nature Reviews Immunology 17, 421 (2017).
doi:10.1038/nri.2017.24

Authors: David J. Rawlings, Genita Metzler, Michelle Wray-Dutra & Shaun W. Jackson
Recent work has provided new insights into how altered B cell-intrinsic signals — through the B cell receptor (BCR) and key co-receptors — function together to promote the pathogenesis of autoimmunity. These combined signals affect B cells at two distinct stages: first, in the selection

Source: Nature Reviews Immunology - April 10, 2017 Category: Allergy & Immunology Authors: David J. Rawlings Genita Metzler Michelle Wray-Dutra Shaun W. Jackson Tags: Review Source Type: research