Trafficking patterns of mononuclear phagocytes
Nature Reviews Immunology 16, 660 (2016).
doi:10.1038/nri.2016.110
Author: Gwendalyn J. Randolph
Gwendalyn Randolph describes a 1981 paper by Ross Gerrity that stimulated her career focus on the trafficking of mononuclear phagocytes. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 9, 2016 Category: Allergy & Immunology Authors: Gwendalyn J. Randolph Tags: Research Highlight Source Type: research
Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis
Nature Reviews Immunology 16, 661 (2016).
doi:10.1038/nri.2016.100
Author: Ken Cadwell
Autophagy has broad functions in immunity, ranging from cell-autonomous defence to coordination of complex multicellular immune responses. The successful resolution of infection and avoidance of autoimmunity necessitates efficient and timely communication between autophagy and pathways that sense the immune environment. The recent literature indicates that (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 2, 2016 Category: Allergy & Immunology Authors: Ken Cadwell Tags: Review Source Type: research
Immunometabolism: Feast or famine to combat infection
Nature Reviews Immunology 16, 597 (2016).
doi:10.1038/nri.2016.109
Author: Elisabeth Kugelberg
Fasting metabolism has opposing roles in maintaining tissue tolerance; anorexia improves survival during bacterial infection whereas it has detrimental effects during viral infection. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 26, 2016 Category: Allergy & Immunology Authors: Elisabeth Kugelberg Tags: Research Highlight Source Type: research
B cells: Genomic reorganization in germinal centres
Nature Reviews Immunology 16, 594 (2016).
doi:10.1038/nri.2016.108
Author: Olive Leavy
The genome of germinal centre B cells undergoes a multilayered reorganization to coordinate transcriptional reprogramming. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 26, 2016 Category: Allergy & Immunology Authors: Olive Leavy Tags: Research Highlight Source Type: research
Emerging roles of p53 and other tumour-suppressor genes in immune regulation
Nature Reviews Immunology 16, 741 (2016).
doi:10.1038/nri.2016.99
Authors: César Muñoz-Fontela, Anna Mandinova, Stuart A. Aaronson & Sam W. Lee
Tumour-suppressor genes are indispensable for the maintenance of genomic integrity. Recently, several of these genes, including those encoding p53, PTEN, RB1 and ARF, have been implicated in immune responses and inflammatory diseases. In particular, the p53 tumour- suppressor pathway is involved in crucial aspects of (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 25, 2016 Category: Allergy & Immunology Authors: C ésar Muñoz-Fontela Anna Mandinova Stuart A. Aaronson Sam W. Lee Tags: Review Source Type: research
Interleukin-33 in health and disease
Nature Reviews Immunology 16, 676 (2016).
doi:10.1038/nri.2016.95
Authors: Foo Yew Liew, Jean-Philippe Girard & Heth Roderick Turnquist
Interleukin-33 (IL-33) — a member of the IL-1 family — was originally described as an inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now, evidence is accumulating that IL-33 also potently stimulates group 2 innate lymphoid (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 18, 2016 Category: Allergy & Immunology Authors: Foo Yew Liew Jean-Philippe Girard Heth Roderick Turnquist Tags: Review Source Type: research
Innate lymphoid cells: Human ILCs face redundancy
Nature Reviews Immunology 16, 596 (2016).
doi:10.1038/nri.2016.106
Author: Kirsty Minton
There are no obvious clinical symptoms of long-term deficiency of innate lymphoid cells in humans, which suggests that their postulated functions might be redundant. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 18, 2016 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Innate immunity: Threat level adjustments
Nature Reviews Immunology 16, 596 (2016).
doi:10.1038/nri.2016.105
Author: Lucy Bird
Regulatory variant of peptidoglycan recognition receptors in Drosophila resolve immune responses according to threat level. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 18, 2016 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
PI3K δ and primary immunodeficiencies
Nature Reviews Immunology 16, 702 (2016).
doi:10.1038/nri.2016.93
Authors: Carrie L. Lucas, Anita Chandra, Sergey Nejentsev, Alison M. Condliffe & Klaus Okkenhaug
Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and activation. Recently, several studies have identified gain-of-function mutations in the phosphoinositide 3-kinase (PI3K) genes PIK3CD (which encodes p110δ) and PIK3R1 (which encodes (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 11, 2016 Category: Allergy & Immunology Authors: Carrie L. Lucas Anita Chandra Sergey Nejentsev Alison M. Condliffe Klaus Okkenhaug Tags: Review Source Type: research
Innate immune cells: A Morrbid way of stayin' alive
Nature Reviews Immunology 16, 595 (2016).
doi:10.1038/nri.2016.104
Author: Olive Leavy
The lncRNA Morrbid controls the lifespan of short-lived myeloid cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 11, 2016 Category: Allergy & Immunology Authors: Olive Leavy Tags: Research Highlight Source Type: research
Innate immunity: IL-1 β activation under scrutiny
Nature Reviews Immunology 16, 594 (2016).
doi:10.1038/nri.2016.102
Author: Elisabeth Kugelberg
Interleukin-1β is activated by the group A Streptococcus protease SpeB during infection. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 11, 2016 Category: Allergy & Immunology Authors: Elisabeth Kugelberg Tags: Research Highlight Source Type: research
T follicular helper cells in space-time
Nature Reviews Immunology 16, 612 (2016).
doi:10.1038/nri.2016.94
Author: Hai Qi
T follicular helper (TFH) cells play a crucial part in the development of humoral immunity by controlling the formation of, and the cellular reactions that occur in, germinal centres. Within these organized lymphoid tissue microstructures, B cells proliferate and somatically mutate to produce (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 29, 2016 Category: Allergy & Immunology Authors: Hai Qi Tags: Review Source Type: research
Innate lymphoid cells: ILC diversity maintained by microbiota
Nature Reviews Immunology 16, 593 (2016).
doi:10.1038/nri.2016.101
Author: Kirsty Minton
Single-cell genomic analysis of ILCs from the mouse small intestine identifies high levels of diversity that are maintained by the commensal microbiota. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 29, 2016 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Asthma and allergy: Old McDonald had a farm (but no asthma)!
Nature Reviews Immunology 16, 535 (2016).
doi:10.1038/nri.2016.97
Author: Olive Leavy
Traditional farming practices in Amish communities help shape the innate immune response and protect against asthma. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 24, 2016 Category: Allergy & Immunology Authors: Olive Leavy Tags: Research Highlight Source Type: research
T Cell responses: Defective mitochondria disrupt CD8+ T cells
Nature Reviews Immunology 16, 534 (2016).
doi:10.1038/nri.2016.98
Author: Olive Leavy
Defective mitochondrial metabolism results in dysfunction CD8+ T cells in chronic viral infections and tumours. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 24, 2016 Category: Allergy & Immunology Authors: Olive Leavy Tags: Research Highlight Source Type: research
