PI3K δ and primary immunodeficiencies

Nature Reviews Immunology 16, 702 (2016).
doi:10.1038/nri.2016.93

Authors: Carrie L. Lucas, Anita Chandra, Sergey Nejentsev, Alison M. Condliffe & Klaus Okkenhaug
Primary immunodeficiencies are inherited disorders of the immune system, often caused by the mutation of genes required for lymphocyte development and activation. Recently, several studies have identified gain-of-function mutations in the phosphoinositide 3-kinase (PI3K) genes PIK3CD (which encodes p110δ) and PIK3R1 (which encodes

Source: Nature Reviews Immunology - September 11, 2016 Category: Allergy & Immunology Authors: Carrie L. Lucas Anita Chandra Sergey Nejentsev Alison M. Condliffe Klaus Okkenhaug Tags: Review Source Type: research