Emerging roles of p53 and other tumour-suppressor genes in immune regulation

Nature Reviews Immunology 16, 741 (2016). doi:10.1038/nri.2016.99 Authors: César Muñoz-Fontela, Anna Mandinova, Stuart A. Aaronson & Sam W. Lee Tumour-suppressor genes are indispensable for the maintenance of genomic integrity. Recently, several of these genes, including those encoding p53, PTEN, RB1 and ARF, have been implicated in immune responses and inflammatory diseases. In particular, the p53 tumour- suppressor pathway is involved in crucial aspects of
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research