Reproductive immunology: B cells, be shells?
Nature Reviews Immunology 17, 2 (2017).
doi:10.1038/nri.2016.145
Author: Yvonne Bordon
B cells may protect against pre-term labour by responding to IL-33. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 22, 2016 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins
Nature Reviews Immunology 17, 130 (2017).
doi:10.1038/nri.2016.129
Authors: Mingui Fu & Perry J. Blackshear
Nearly 60 CCCH zinc finger proteins have been identified in humans and mice. These proteins are involved in the regulation of multiple steps of RNA metabolism, including mRNA splicing, polyadenylation, transportation, translation and decay. Several CCCH zinc finger proteins, such as tristetraprolin (TTP), roquin 1 (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 18, 2016 Category: Allergy & Immunology Authors: Mingui Fu Perry J. Blackshear Tags: Review Source Type: research
Haematopoiesis: HSC function determined by epigenetic memory
Nature Reviews Immunology 17, 5 (2017).
doi:10.1038/nri.2016.140
Author: Kirsty Minton
The functional behaviour of haematopoietic stem cells is determined in a cell-autonomous manner by clone-specific epigenetic modifications. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 11, 2016 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Infection: TSLP complements neutrophil killing of bacteria
Nature Reviews Immunology 17, 4 (2017).
doi:10.1038/nri.2016.139
Author: Elisabeth Kugelberg
Thymic stromal lymphopoietin increases the killing of methicillin-resistant Staphylococcus aureus in a neutrophil- and complement-dependent manner. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 11, 2016 Category: Allergy & Immunology Authors: Elisabeth Kugelberg Tags: Research Highlight Source Type: research
Allergy: Pollutants drive atopic dermatitis
Nature Reviews Immunology 17, 1 (2017).
doi:10.1038/nri.2016.141
Author: Yvonne Bordon
Pollutants activate the aryl hydrocarbon receptor to upregulate type 2 cytokines and neurotrophic factors that drive atopic dermatitis. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 11, 2016 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting
Nature Reviews Immunology 17, 60 (2017).
doi:10.1038/nri.2016.124
Authors: Vivianne Malmström, Anca I. Catrina & Lars Klareskog
Patients with rheumatoid arthritis can be divided into two major subsets characterized by the presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of rheumatoid factor (RF). The antibody-positive subset of disease, also known as seropositive rheumatoid arthritis, constitutes approximately two-thirds of all (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 4, 2016 Category: Allergy & Immunology Authors: Vivianne Malmstr öm Anca I. Catrina Lars Klareskog Tags: Review Source Type: research
Cytokine networks in neuroinflammation
Nature Reviews Immunology 17, 49 (2017).
doi:10.1038/nri.2016.123
Authors: Burkhard Becher, Sabine Spath & Joan Goverman
Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. There is an emerging understanding of the role that cytokines play in normal homeostatic tissue function and how dysregulation of these cytokine networks is associated with pathological conditions. The (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 4, 2016 Category: Allergy & Immunology Authors: Burkhard Becher Sabine Spath Joan Goverman Tags: Review Source Type: research
Human immune system variation
Nature Reviews Immunology 17, 21 (2017).
doi:10.1038/nri.2016.125
Authors: Petter Brodin & Mark M. Davis
The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. The range of (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 4, 2016 Category: Allergy & Immunology Authors: Petter Brodin Mark M. Davis Tags: Review Source Type: research
Tumour immunology: Interrogating intratumoral Treg cells
Nature Reviews Immunology 17, 4 (2017).
doi:10.1038/nri.2016.137
Author: Lydia Shipman
Two studies have characterized a distinct molecular signature of intratumoral CD4+ regulatory T cells from various tumours that correlates with cancer prognosis. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 4, 2016 Category: Allergy & Immunology Authors: Lydia Shipman Tags: Research Highlight Source Type: research
Correlates of protection against Neisseria Meningitidis
Nature Reviews Immunology 17, 3 (2017).
doi:10.1038/nri.2016.135
Author: Andrew Pollard
Andrew Pollard describes a 1921 study by George Heist and colleagues that pointed to antibody as a correlate of protection against meningococcal disease. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 4, 2016 Category: Allergy & Immunology Authors: Andrew Pollard Tags: Research Highlight Source Type: research
Dendritic cell migration in health and disease
Nature Reviews Immunology 17, 30 (2017).
doi:10.1038/nri.2016.116
Authors: Tim Worbs, Swantje I. Hammerschmidt & Reinhold Förster
Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune responses. Recent comprehensive studies have highlighted the importance of DC migration in the maintenance of immune surveillance and (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 27, 2016 Category: Allergy & Immunology Authors: Tim Worbs Swantje I. Hammerschmidt Reinhold F örster Tags: Review Source Type: research
Early local immune defences in the respiratory tract
Nature Reviews Immunology 17, 7 (2017).
doi:10.1038/nri.2016.117
Authors: Akiko Iwasaki, Ellen F. Foxman & Ryan D. Molony
The respiratory immune response consists of multiple tiers of cellular responses that are engaged in a sequential manner in order to control infections. The stepwise engagement of effector functions with progressively increasing host fitness costs limits tissue damage. In addition, specific mechanisms are in place (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 27, 2016 Category: Allergy & Immunology Authors: Akiko Iwasaki Ellen F. Foxman Ryan D. Molony Tags: Review Source Type: research
Immunoregulation by members of the TGF β superfamily
Nature Reviews Immunology 16, 723 (2016).
doi:10.1038/nri.2016.112
Authors: WanJun Chen & Peter ten Dijke
The transforming growth factor-β (TGFβ) superfamily is encoded by 33 genes and includes TGFβ, bone morphogenetic proteins (BMPs) and activins. Although TGFβ is well recognized as a crucial regulator of immune responses, the immunoregulatory functions of other TGFβ family members are less clear. However, recent (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 24, 2016 Category: Allergy & Immunology Authors: WanJun Chen Peter ten Dijke Tags: Review Source Type: research
Macrophages: Macrophage muscle man
Nature Reviews Immunology 16, 720 (2016).
doi:10.1038/nri.2016.133
Author: Lucy Bird
Macrophages expressing PPARγ support skeletal muscle regeneration by inducing secretion of the myoblast growth factor GDF3. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 24, 2016 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Infection: Interferons suppress antibody responses
Nature Reviews Immunology 16, 720 (2016).
doi:10.1038/nri.2016.128
Author: Elisabeth Kugelberg
Type I interferons induced by chronic viral infections suppress the induction of early neutralizing antibody responses. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 24, 2016 Category: Allergy & Immunology Authors: Elisabeth Kugelberg Tags: Research Highlight Source Type: research
