Reply: Breastfeeding-related maternal microchimerism
Nature Reviews Immunology 17, 730 (2017).
doi:10.1038/nri.2017.117
Authors: Jeremy M. Kinder, Ina A. Stelzer, Petra C. Arck & Sing Sing Way
We recently reviewed pregnancy-imprinted immunological shifts in mothers and offspring from the perspective of genetically foreign cells that establish microchimerism in both individuals after parturition (Immunological implications of pregnancy-induced microchimerism. Nat. Rev. Immunol.17, 483–494 (2017)). Expanded tolerance between mothers and their (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 3, 2017 Category: Allergy & Immunology Authors: Jeremy M. Kinder Ina A. Stelzer Petra C. Arck Sing Sing Way Tags: Reply Source Type: research
Breastfeeding-related maternal microchimerism
Nature Reviews Immunology 17, 729 (2017).
doi:10.1038/nri.2017.115
Authors: Jean-Pierre Molès, Edouard Tuaillon, Chipepo Kankasa, Anne-Sophie Bedin, Nicolas Nagot, Arnaud Marchant, Joann M. McDermid & Philippe Van de Perre
We were fascinated by the Review article by Jeremy M. Kinder et al. (Immunological implications of pregnancy-induced microchimerism. Nat. Rev. Immunol.17, 483–494 (2017)), which discusses the bidirectional exchange of maternal and fetal cells during pregnancy and the potential benefits and (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - October 3, 2017 Category: Allergy & Immunology Authors: Jean-Pierre Mol è s Edouard Tuaillon Chipepo Kankasa Anne-Sophie Bedin Nicolas Nagot Arnaud Marchant Joann M. McDermid Philippe Van de Perre Tags: Correspondence Source Type: research
Autoimmunity: LKB1 helps Treg cells battle exhaustion
Nature Reviews Immunology 17, 592 (2017).
doi:10.1038/nri.2017.116
Author: Megan Cully
LKB1 protects regulatory T cells from exhaustion, allowing them to efficiently control T helper 2 cell responses. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 27, 2017 Category: Allergy & Immunology Authors: Megan Cully Tags: Research Highlight Source Type: research
The spectrum of T cell metabolism in health and disease
Nature Reviews Immunology 18, 19 (2018).
doi:10.1038/nri.2017.99
Authors: Glenn R. Bantug, Lorenzo Galluzzi, Guido Kroemer & Christoph Hess
In healthy individuals, metabolically quiescent T cells survey lymph nodes and peripheral tissues in search of cognate antigens. During infection, T cells that encounter cognate antigens are activated and — in a context-specific manner — proliferate and/or differentiate to become effector T cells. This process (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 25, 2017 Category: Allergy & Immunology Authors: Glenn R. Bantug Lorenzo Galluzzi Guido Kroemer Christoph Hess Tags: Review Source Type: research
Complement in cancer: untangling an intricate relationship
Nature Reviews Immunology 18, 5 (2018).
doi:10.1038/nri.2017.97
Authors: Edimara S. Reis, Dimitrios C. Mastellos, Daniel Ricklin, Alberto Mantovani & John D. Lambris
In tumour immunology, complement has traditionally been considered as an adjunctive component that enhances the cytolytic effects of antibody-based immunotherapies, such as rituximab. Remarkably, research in the past decade has uncovered novel molecular mechanisms linking imbalanced complement activation in the tumour microenvironment with inflammation and (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 18, 2017 Category: Allergy & Immunology Authors: Edimara S. Reis Dimitrios C. Mastellos Daniel Ricklin Alberto Mantovani John D. Lambris Tags: Review Source Type: research
γ δ T cells in homeostasis and host defence of epithelial barrier tissues
Nature Reviews Immunology 17, 733 (2017).
doi:10.1038/nri.2017.101
Authors: Morten M. Nielsen, Deborah A. Witherden & Wendy L. Havran
Epithelial surfaces line the body and provide a crucial interface between the body and the external environment. Tissue-resident epithelial γδ T cells represent a major T cell population in the epithelial tissues and are ideally positioned to carry out barrier surveillance and aid in tissue (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 18, 2017 Category: Allergy & Immunology Authors: Morten M. Nielsen Deborah A. Witherden Wendy L. Havran Tags: Review Source Type: research
Neutrophils: Interfering with intestinal inflammation
Nature Reviews Immunology 17, 594 (2017).
doi:10.1038/nri.2017.113
Author: Shimona Starling
IFNλ can modulate the function of neutrophils and suppress intestinal inflammation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 18, 2017 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
Neuroimmunology: JAK in the itch
Nature Reviews Immunology 17, 591 (2017).
doi:10.1038/nri.2017.114
Author: Yvonne Bordon
Chronic itch is driven by IL-4 receptor- and JAK1-mediated signalling in sensory neurons. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 18, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Functions of tissue-resident eosinophils
Nature Reviews Immunology 17, 746 (2017).
doi:10.1038/nri.2017.95
Authors: Peter F. Weller & Lisa A. Spencer
Eosinophils are a prominent cell type in particular host responses such as the response to helminth infection and allergic disease. Their effector functions have been attributed to their capacity to release cationic proteins stored in cytoplasmic granules by degranulation. However, eosinophils are now being recognized (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 11, 2017 Category: Allergy & Immunology Authors: Peter F. Weller Lisa A. Spencer Tags: Review Source Type: research
Immune homeostasis: Regulatory ILCs don't rely on FOXP3
Nature Reviews Immunology 17, 594 (2017).
doi:10.1038/nri.2017.107
Author: Yvonne Bordon
The identification of a regulatory innate lymphoid cell subset in the intestine. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 11, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Mucosal immunology: Probiotic induction of tolerogenic T cells in the gut
Nature Reviews Immunology 17, 592 (2017).
doi:10.1038/nri.2017.110
Author: Katharine H. Wrighton
A probiotic induces CD4+ T cell differentiation into tolerogenic double-positive intraepithelial lymphocytes by activating their aryl hydrocarbon receptor. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 11, 2017 Category: Allergy & Immunology Authors: Katharine H. Wrighton Tags: Research Highlight Source Type: research
T cells: Proteasome dictates CD8+ T cell fate
Nature Reviews Immunology 17, 592 (2017).
doi:10.1038/nri.2017.109
Author: Shimona Starling
Endogenous proteasome activity can modulate the fate and function of CD8+ T cells. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 11, 2017 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
Organ-specific protection mediated by cooperation between vascular and epithelial barriers
Nature Reviews Immunology 17, 761 (2017).
doi:10.1038/nri.2017.100
Authors: Ilaria Spadoni, Giulia Fornasa & Maria Rescigno
Immune privilege is a complex process that protects organs from immune-mediated attack and damage. It is accomplished by a series of cellular barriers that both control immune cell entry and promote the development of tolerogenic immune cells. In this Review, we describe the vascular endothelial (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - September 4, 2017 Category: Allergy & Immunology Authors: Ilaria Spadoni Giulia Fornasa Maria Rescigno Tags: Review Source Type: research
Synthetic immune niches for cancer immunotherapy
Nature Reviews Immunology 18, 212 (2018).
doi:10.1038/nri.2017.89
Authors: Jorieke Weiden, Jurjen Tel & Carl G. Figdor
Cancer immunotherapy can successfully promote long-term anticancer immune responses, although there is still only a limited number of patients who benefit from such treatment, and it can sometimes have severe treatment-associated adverse events. Compared with systemic immunomodulation, local immunomodulation may enable more effective treatment at (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 30, 2017 Category: Allergy & Immunology Authors: Jorieke Weiden Jurjen Tel Carl G. Figdor Tags: Perspectives Source Type: research
Type 2 immunity in tissue repair and fibrosis
Nature Reviews Immunology 18, 62 (2018).
doi:10.1038/nri.2017.90
Authors: Richard L. Gieseck, Mark S. Wilson & Thomas A. Wynn
Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this immune response is commonly observed in tissues during allergic inflammation or infection with helminth parasites. However, many of the key cell types associated with type 2 immune responses — (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - August 30, 2017 Category: Allergy & Immunology Authors: Richard L. Gieseck Mark S. Wilson Thomas A. Wynn Tags: Review Source Type: research
