Complement in cancer: untangling an intricate relationship

Nature Reviews Immunology 18, 5 (2018). doi:10.1038/nri.2017.97 Authors: Edimara S. Reis, Dimitrios C. Mastellos, Daniel Ricklin, Alberto Mantovani & John D. Lambris In tumour immunology, complement has traditionally been considered as an adjunctive component that enhances the cytolytic effects of antibody-based immunotherapies, such as rituximab. Remarkably, research in the past decade has uncovered novel molecular mechanisms linking imbalanced complement activation in the tumour microenvironment with inflammation and
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research