Inflammasome: Looking death in the eye
Nature Reviews Immunology 18, 4 (2018).
doi:10.1038/nri.2017.154
Author: Kirsty Minton
Death of the retinal epithelium in age-related macular degeneration involves cGAS-dependent noncanonical inflammasome activation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 22, 2017 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
Innate immunity: Revealing the secrets of IL-1 secretion
Nature Reviews Immunology 18, 2 (2018).
doi:10.1038/nri.2017.155
Author: Shimona Starling
IL-1 is released from living macrophages by gasdermin D pore formation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 22, 2017 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
Plasmacytoid dendritic cells: Division of labour
Nature Reviews Immunology 18, 2 (2018).
doi:10.1038/nri.2017.153
Author: Lucy Bird
Plasmacytoid dendritic cells diversify in response to a single stimulus. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 22, 2017 Category: Allergy & Immunology Authors: Lucy Bird Tags: Research Highlight Source Type: research
Viral subversion of B cell responses within secondary lymphoid organs
Nature Reviews Immunology 18, 255 (2018).
doi:10.1038/nri.2017.133
Authors: Mirela Kuka & Matteo Iannacone
Antibodies play a crucial role in virus control. The production of antibodies requires virus-specific B cells to encounter viral antigens in lymph nodes, become activated, interact with different immune cells, proliferate and enter specific differentiation programmes. Each step occurs in distinct lymph node niches, requiring (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 18, 2017 Category: Allergy & Immunology Authors: Mirela Kuka Matteo Iannacone Tags: Review Source Type: research
Towards personalized, tumour-specific, therapeutic vaccines for cancer
Nature Reviews Immunology 18, 168 (2018).
doi:10.1038/nri.2017.131
Authors: Zhuting Hu, Patrick A. Ott & Catherine J. Wu
Cancer vaccines, which are designed to amplify tumour-specific T cell responses through active immunization, have long been envisioned as a key tool of effective cancer immunotherapy. Despite a clear rationale for such vaccines, extensive past efforts were unsuccessful in mediating clinically relevant antitumour activity in (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 11, 2017 Category: Allergy & Immunology Authors: Zhuting Hu Patrick A. Ott Catherine J. Wu Tags: Review Source Type: research
Immunometabolism in 2017: Driving immunity: all roads lead to metabolism
Nature Reviews Immunology 18, 81 (2018).
doi:10.1038/nri.2017.139
Authors: Edward J. Pearce & Erika L. Pearce
In 2017, studies of cellular metabolism broadly permeated immunological research. Accumulating data support the view that understanding how metabolism regulates immune cell function could provide new therapeutic opportunities for the many diseases associated with immune system dysregulation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 11, 2017 Category: Allergy & Immunology Authors: Edward J. Pearce Erika L. Pearce Tags: Year in Review Source Type: research
Innate immunity: Platelets on the prowl
Nature Reviews Immunology 18, 3 (2018).
doi:10.1038/nri.2017.147
Author: Yvonne Bordon
Platelets actively migrate at inflamed sites and can collect and bundle bacteria and promote neutrophil activation. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 11, 2017 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research
Vaccines in 2017: Closing in on a Zika virus vaccine
Nature Reviews Immunology 18, 89 (2018).
doi:10.1038/nri.2017.132
Authors: Michael S. Diamond & Carolyn B. Coyne
Over the past 2 years, Zika virus (ZIKV) has emerged as a pathogen capable of causing devastating congenital malformations in the developing fetus and significant neurological disease in adults. In 2017, substantial progress has been made towards the development, immunological analysis and preclinical evaluation of vaccine platforms to prevent the pathologies associated with ZIKV infection. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 4, 2017 Category: Allergy & Immunology Authors: Michael S. Diamond Carolyn B. Coyne Tags: Year in Review Source Type: research
Chemokines: Moving on up
Nature Reviews Immunology 18, 1 (2018).
doi:10.1038/nri.2017.137
Author: Kirsty Minton
Chemotaxis of myeloid cells in response to CCL19 and CXCL12 involves temporal sensing of an increasing source concentration of chemokine. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - December 4, 2017 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
ITIMs: episode 1 of the inhibitory saga
Nature Reviews Immunology 18, 4 (2018).
doi:10.1038/nri.2017.134
Author: Eric Vivier
Eric Vivier recounts how the initial description of the ITIM motif in FcγRIIB helped to launch the field of inhibitory immune receptors. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 27, 2017 Category: Allergy & Immunology Authors: Eric Vivier Tags: Research Highlight Source Type: research
Microglia and macrophages in brain homeostasis and disease
Nature Reviews Immunology 18, 225 (2018).
doi:10.1038/nri.2017.125
Authors: Qingyun Li & Ben A. Barres
Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that are increasingly recognized to be essential players in the development, homeostasis and diseases of the central nervous system. With the availability of new genetic, molecular and pharmacological tools, considerable advances have been made towards (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 20, 2017 Category: Allergy & Immunology Authors: Qingyun Li Ben A. Barres Tags: Review Source Type: research
The diverse functions of the PD1 inhibitory pathway
Nature Reviews Immunology 18, 153 (2018).
doi:10.1038/nri.2017.108
Authors: Arlene H. Sharpe & Kristen E. Pauken
T cell activation is a highly regulated process involving peptide–MHC engagement of the T cell receptor and positive costimulatory signals. Upon activation, coinhibitory 'checkpoints', including programmed cell death protein 1 (PD1), become induced to regulate T cells. PD1 has an essential role in balancing protective (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 13, 2017 Category: Allergy & Immunology Authors: Arlene H. Sharpe Kristen E. Pauken Tags: Review Source Type: research
Dendritic cells: Managing migration
Nature Reviews Immunology 17, 730 (2017).
doi:10.1038/nri.2017.128
Author: Kirsty Minton
Lysosomal calcium signalling links antigen uptake by tissue dendritic cells to migration to the lymph nodes. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 13, 2017 Category: Allergy & Immunology Authors: Kirsty Minton Tags: Research Highlight Source Type: research
MHC molecules: Immune editing shapes the cancer landscape
Nature Reviews Immunology 17, 729 (2017).
doi:10.1038/nri.2017.129
Author: Shimona Starling
HLA variation or loss is associated with immune editing in human tumours. (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 13, 2017 Category: Allergy & Immunology Authors: Shimona Starling Tags: Research Highlight Source Type: research
How poverty affects diet to shape the microbiota and chronic disease
Nature Reviews Immunology 18, 279 (2018).
doi:10.1038/nri.2017.121
Authors: Christy A. Harrison & Douglas Taren
Here, we discuss the link between nutrition, non-communicable chronic diseases and socio-economic standing, with a special focus on the microbiota. We provide a theoretical framework and several lines of evidence from both animal and human studies that support the idea that income inequality is an (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 7, 2017 Category: Allergy & Immunology Authors: Christy A. Harrison Douglas Taren Tags: Perspectives Source Type: research
