The diverse functions of the PD1 inhibitory pathway

Nature Reviews Immunology 18, 153 (2018). doi:10.1038/nri.2017.108 Authors: Arlene H. Sharpe & Kristen E. Pauken T cell activation is a highly regulated process involving peptide–MHC engagement of the T cell receptor and positive costimulatory signals. Upon activation, coinhibitory 'checkpoints', including programmed cell death protein 1 (PD1), become induced to regulate T cells. PD1 has an essential role in balancing protective
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research