The diverse functions of the PD1 inhibitory pathway
Nature Reviews Immunology 18, 153 (2018).
doi:10.1038/nri.2017.108
Authors: Arlene H. Sharpe & Kristen E. Pauken
T cell activation is a highly regulated process involving peptide–MHC engagement of the T cell receptor and positive costimulatory signals. Upon activation, coinhibitory 'checkpoints', including programmed cell death protein 1 (PD1), become induced to regulate T cells. PD1 has an essential role in balancing protective
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Arlene H. Sharpe Kristen E. Pauken Tags: Review Source Type: research
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