Mitochondrial DNA in innate immune responses and inflammatory pathology

Nature Reviews Immunology 17, 363 (2017). doi:10.1038/nri.2017.21 Authors: A. Phillip West & Gerald S. Shadel Mitochondrial DNA (mtDNA) — which is well known for its role in oxidative phosphorylation and maternally inherited mitochondrial diseases — is increasingly recognized as an agonist of the innate immune system that influences antimicrobial responses and inflammatory pathology. On entering the cytoplasm, extracellular space or
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research