Immunogenic cell death in cancer and infectious disease
Nature Reviews Immunology 17, 97 (2017).
doi:10.1038/nri.2016.107
Authors: Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel & Guido Kroemer
Immunogenicity depends on two key factors: antigenicity and adjuvanticity. The presence of exogenous or mutated antigens explains why infected cells and malignant cells can initiate an adaptive immune response provided that the cells also emit adjuvant signals as a consequence of cellular stress and death.
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Lorenzo Galluzzi Aitziber Buqu é Oliver Kepp Laurence Zitvogel Guido Kroemer Tags: Review Source Type: research