The hygiene hypothesis in autoimmunity: the role of pathogens and commensals

Nature Reviews Immunology 18, 105 (2018). doi:10.1038/nri.2017.111 Author: Jean-François Bach The incidence of autoimmune diseases has been steadily rising. Concomitantly, the incidence of most infectious diseases has declined. This observation gave rise to the hygiene hypothesis, which postulates that a reduction in the frequency of infections contributes directly to the increase in the frequency of
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research