Does niche competition determine the origin of tissue-resident macrophages?

Nature Reviews Immunology 17, 451 (2017). doi:10.1038/nri.2017.42 Authors: Martin Guilliams & Charlotte L. Scott Most tissue-resident macrophages are derived from embryonic precursors but, under certain circumstances, circulating monocytes can differentiate into self-maintaining tissue-resident macrophages that resemble their embryonic counterparts. In this Opinion article, we propose that distinct macrophage precursors have an almost identical potential to develop into resident macrophages
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Perspectives Source Type: research