Improving immune – vascular crosstalk for cancer immunotherapy
Nature Reviews Immunology 18, 195 (2018).
doi:10.1038/nri.2017.145
Authors: Yuhui Huang, Betty Y. S. Kim, Charles K. Chan, Stephen M. Hahn, Irving L. Weissman & Wen Jiang
The vasculature of tumours is highly abnormal and dysfunctional. Consequently, immune effector cells have an impaired ability to penetrate solid tumours and often exhibit compromised functions. Normalization of the tumour vasculature can enhance tissue perfusion and improve immune effector cell infiltration, leading to immunotherapy potentiation.
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Yuhui Huang Betty Y. S. Kim Charles K. Chan Stephen M. Hahn Irving L. Weissman Wen Jiang Tags: Perspectives Source Type: research