Improving immune – vascular crosstalk for cancer immunotherapy

Nature Reviews Immunology 18, 195 (2018). doi:10.1038/nri.2017.145 Authors: Yuhui Huang, Betty Y. S. Kim, Charles K. Chan, Stephen M. Hahn, Irving L. Weissman & Wen Jiang The vasculature of tumours is highly abnormal and dysfunctional. Consequently, immune effector cells have an impaired ability to penetrate solid tumours and often exhibit compromised functions. Normalization of the tumour vasculature can enhance tissue perfusion and improve immune effector cell infiltration, leading to immunotherapy potentiation.
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Perspectives Source Type: research