Inflammasomes: mechanism of assembly, regulation and signalling

Nature Reviews Immunology 16, 407 (2016). doi:10.1038/nri.2016.58 Authors: Petr Broz & Vishva M. Dixit Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and
Source: Nature Reviews Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research