Tumour metabolism: Metabolic flexibility
Nature Reviews Cancer 16, 617 (2016).
doi:10.1038/nrc.2016.101
Author: Anna Dart
Glutamine supports cancer cell growth, yet cancer cells can survive glutamine depletion. Reid et al. reveal a novel pathway exploited by tumours to adapt to glutamine starvation through the activation of inhibitor of nuclear factor-κB (NF-κB) kinase subunit-β (IKKβ). Independently of inducing NF-κB transcriptional (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 22, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
The current state of cancer metabolism
Nature Reviews Cancer 16, 613 (2016).
doi:10.1038/nrc.2016.100
Authors: Rob A. Cairns & Tak W. Mak
The study of cancer metabolism has grown exponentially over the past decade. Although the initial observations by Otto Warburg and his contemporaries during the early twentieth century strongly suggested that core cellular metabolism was altered during the process of malignant transformation, the oncogene revolution and (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 22, 2016 Category: Cancer & Oncology Authors: Rob A. Cairns Tak W. Mak Tags: Foreword Source Type: research
Metabolic control of epigenetics in cancer
Nature Reviews Cancer 16, 694 (2016).
doi:10.1038/nrc.2016.82
Authors: Adam Kinnaird, Steven Zhao, Kathryn E. Wellen & Evangelos D. Michelakis
Alterations in the epigenome and metabolism both affect molecular rewiring in cancer cells and facilitate cancer development and progression. However, recent evidence suggests the existence of important bidirectional regulatory mechanisms between metabolic remodelling and the epigenome (specifically methylation and acetylation of histones) in cancer. Most (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 15, 2016 Category: Cancer & Oncology Authors: Adam Kinnaird Steven Zhao Kathryn E. Wellen Evangelos D. Michelakis Tags: Review Source Type: research
Serine and one-carbon metabolism in cancer
Nature Reviews Cancer 16, 650 (2016).
doi:10.1038/nrc.2016.81
Authors: Ming Yang & Karen H. Vousden
The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 15, 2016 Category: Cancer & Oncology Authors: Ming Yang Karen H. Vousden Tags: Review Source Type: research
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
Nature Reviews Cancer 16, 635 (2016).
doi:10.1038/nrc.2016.77
Author: Nissim Hay
In recent years there has been a growing interest among cancer biologists in cancer metabolism. This Review summarizes past and recent advances in our understanding of the reprogramming of glucose metabolism in cancer cells, which is mediated by oncogenic drivers and by the undifferentiated character (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 15, 2016 Category: Cancer & Oncology Authors: Nissim Hay Tags: Review Source Type: research
Tumour metabolism: The sugar-free, full-fat diet
Nature Reviews Cancer 16, 615 (2016).
doi:10.1038/nrc.2016.99
Author: M. Teresa Villanueva
Acidosis reprograms the metabolism of cancer cells toward fatty acid oxidation by downregulating acetyl-CoA carboxylase ACC2 through histone deacetylation (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 11, 2016 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
The interplay between cell signalling and the mevalonate pathway in cancer
Nature Reviews Cancer 16, 718 (2016).
doi:10.1038/nrc.2016.76
Authors: Peter J. Mullen, Rosemary Yu, Joseph Longo, Michael C. Archer & Linda Z. Penn
The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 25, 2016 Category: Cancer & Oncology Authors: Peter J. Mullen Rosemary Yu Joseph Longo Michael C. Archer Linda Z. Penn Tags: Review Source Type: research
The metabolic fate of acetate in cancer
Nature Reviews Cancer 16, 708 (2016).
doi:10.1038/nrc.2016.87
Authors: Zachary T. Schug, Johan Vande Voorde & Eyal Gottlieb
Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 25, 2016 Category: Cancer & Oncology Authors: Zachary T. Schug Johan Vande Voorde Eyal Gottlieb Tags: Review Source Type: research
Tumour metabolism: Adapting to harsh conditions
Nature Reviews Cancer 16, 616 (2016).
doi:10.1038/nrc.2016.98
Author: Sarah Seton-Rogers
Chae et al. show that mitochondrially-localized AKT phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) to promote tumour cell growth and survival in hypoxic conditions. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 25, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Tumour metabolism: Feeding your friends
Nature Reviews Cancer 16, 616 (2016).
doi:10.1038/nrc.2016.96
Author: Anna Dart
Sousa et al. demonstrate a reciprocal metabolic cross-talk between pancreatic stellate cells (PSCs) and pancreatic tumour cells whereby secreted autophagic alanine from PSCs is taken up by tumour cells and used as an alternative carbon source to support tumour growth. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 25, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
The biology and function of fibroblasts in cancer
Nature Reviews Cancer 16, 582 (2016).
doi:10.1038/nrc.2016.73
Author: Raghu Kalluri
Among all cells, fibroblasts could be considered the cockroaches of the human body. They survive severe stress that is usually lethal to all other cells, and they are the only normal cell type that can be live-cultured from post-mortem and decaying tissue. Their resilient adaptation (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 22, 2016 Category: Cancer & Oncology Authors: Raghu Kalluri Tags: Review Source Type: research
Engineered T cells: the promise and challenges of cancer immunotherapy
Nature Reviews Cancer 16, 566 (2016).
doi:10.1038/nrc.2016.97
Authors: Andrew D. Fesnak, Carl H. June & Bruce L. Levine
The immune system evolved to distinguish non-self from self to protect the organism. As cancer is derived from our own cells, immune responses to dysregulated cell growth present a unique challenge. This is compounded by mechanisms of immune evasion and immunosuppression that develop in the (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 22, 2016 Category: Cancer & Oncology Authors: Andrew D. Fesnak Carl H. June Bruce L. Levine Tags: Review Source Type: research
Oncogenes: piRNA flies in
Nature Reviews Cancer 16, 551 (2016).
doi:10.1038/nrc.2016.95
Author: Anna Dart
It is recognized that in a number of different soma-derived human cancers, expression of genes typically restricted to germ cells can become reactivated, and amongst these are components of the PIWI-interacting RNA (piRNA) pathway. This phenomenon of germline gene re-expression has also been shown to (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 22, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Leukaemia: Common driver gets new oncogenic mechanism
Nature Reviews Cancer 16, 551 (2016).
doi:10.1038/nrc.2016.94
Author: Anna Dart
Mutations in the genes isocitrate dehydrogenase 1 (IDH1) and tet methylcytosine dioxygenase 2 (TET2) are common drivers in myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML), which has led to the assumption that mutant IDH1 might drive alterations in DNA methylation (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 22, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Metastasis: RIP endothelial cells
Nature Reviews Cancer 16, 551 (2016).
doi:10.1038/nrc.2016.93
Author: Anna Dart
In order to metastasize, circulating tumour cells must exit the bloodstream by passing through the endothelial barrier. This process of extravasation is poorly understood. Strilic et al. now provide evidence that tumour cells can induce necroptosis of endothelial cells to drive transendothelial migration and (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 22, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
