Leukaemia: Common driver gets new oncogenic mechanism

Nature Reviews Cancer 16, 551 (2016). doi:10.1038/nrc.2016.94 Author: Anna Dart Mutations in the genes isocitrate dehydrogenase 1 (IDH1) and tet methylcytosine dioxygenase 2 (TET2) are common drivers in myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML), which has led to the assumption that mutant IDH1 might drive alterations in DNA methylation
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research