Cancer risk: Generating tumours: it's all in the balance
Nature Reviews Cancer 16, 753 (2016).
doi:10.1038/nrc.2016.137
Author: Gemma K. Alderton
Two papers examine the influence of different stem cell characteristics on tumorigenesis in an organ-specific and age-associated manner, continuing the debate on the influence of intrinsic and extrinsic factors on cancer risk. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2016 Category: Cancer & Oncology Authors: Gemma K. Alderton Tags: Research Highlight Source Type: research
Angiogenesis: Going with the flow
Nature Reviews Cancer 16, 751 (2016).
doi:10.1038/nrc.2016.127
Author: M. Teresa Villanueva
Two studies have revealed two possible mechanisms that might explain why VEGF inhibition can be rendered ineffective (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2016 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
Cancer nanomedicine: progress, challenges and opportunities
Nature Reviews Cancer 17, 20 (2017).
doi:10.1038/nrc.2016.108
Authors: Jinjun Shi, Philip W. Kantoff, Richard Wooster & Omid C. Farokhzad
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. Considerable technological success has been achieved in this field, but the main obstacles to nanomedicine becoming a (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2016 Category: Cancer & Oncology Authors: Jinjun Shi Philip W. Kantoff Richard Wooster Omid C. Farokhzad Tags: Review Source Type: research
The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia
Nature Reviews Cancer 17, 5 (2017).
doi:10.1038/nrc.2016.112
Authors: Adam S. Sperling, Christopher J. Gibson & Benjamin L. Ebert
Myelodysplastic syndrome (MDS) is a clonal disease that arises from the expansion of mutated haematopoietic stem cells. In a spectrum of myeloid disorders ranging from clonal haematopoiesis of indeterminate potential (CHIP) to secondary acute myeloid leukaemia (sAML), MDS is distinguished by the presence of peripheral (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2016 Category: Cancer & Oncology Authors: Adam S. Sperling Christopher J. Gibson Benjamin L. Ebert Tags: Review Source Type: research
From Krebs to clinic: glutamine metabolism to cancer therapy
Nature Reviews Cancer 16, 773 (2016).
doi:10.1038/nrc.2016.131
Author: Brian J. Altman, Zachary E. Stine & Chi V. Dang
Nature Reviews Cancer16, 619–634 (2016)Reference 32 was incorrectly cited on page 626 and references 128, 129, 134 and 135 were incorrectly cited in Table 1. These have now been replaced with the correct references. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2016 Category: Cancer & Oncology Authors: Brian J. Altman Zachary E. Stine Chi V. Dang Tags: Corrigendum Source Type: research
Obesity promotes prostate cancer invasion
Nature Reviews Cancer 16, 773 (2016).
doi:10.1038/nrc.2016.130
Nature Reviews Cancer16, 7010.1038/nrc.2016.129(2016)In the original version of this article the DOI number was incorrect. This error has been corrected in the HTML version of the article. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2016 Category: Cancer & Oncology Tags: Correction Source Type: research
Pancreatic cancer: Fast or slow?
Nature Reviews Cancer 16, 755 (2016).
doi:10.1038/nrc.2016.128
Author: Sarah Seton-Rogers
An analysis of pancreatic ductal adenocarcinoma genomes indicates that many of these tumours undergo polyploidization and chromothripsis, leading to rapid acquisition of genetic changes required for tumour progression. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Tumorigenesis: Networking: a survival guide
Nature Reviews Cancer 16, 752 (2016).
doi:10.1038/nrc.2016.125
Author: Anna Dart
A subset of cancer cells is dependent on a large, stable multi-protein complex called the epichaperome for survival under conditions of stress. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Tumour microenvironment: That gut feeling
Nature Reviews Cancer 16, 756 (2016).
doi:10.1038/nrc.2016.122
Author: Anna Dart
Daillère et al. have identified two bacterial species that mediate systemic and tumour-infiltrating T cell responses associated with the antitumour efficacy of the chemotherapy drug cyclophosphamide. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 3, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Lymphoma: Customized therapeutic delivery
Nature Reviews Cancer 16, 756 (2016).
doi:10.1038/nrc.2016.121
Author: Sarah Seton-Rogers
Boice, Salloum, Mourcin et al. show that HVEM is an important tumour suppressor in lymphomas and that direct delivery of a soluble HVEM peptide using engineered T cells might be therapeutically beneficial. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 2, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Immunology: Skin inflammation predisposes to cancer
Nature Reviews Cancer 16, 678 (2016).
doi:10.1038/nrc.2016.120
Author: Gemma K. Alderton
Inflammasome complexes are important effectors of innate immune responses, and chronic inflammation in the gut has been linked to tumorigenesis. Zhong et al. have found germline gain-of-function mutations in the gene encoding the inflammasome receptor, NLRP1. These mutations cause two skin disorders that are (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 23, 2016 Category: Cancer & Oncology Authors: Gemma K. Alderton Tags: Research Highlight Source Type: research
Tumour metabolism: Targeting proline metabolism?
Nature Reviews Cancer 16, 678 (2016).
doi:10.1038/nrc.2016.119
Author: Gemma K. Alderton
Proline is a non-essential amino acid and Sahu et al. show that some cancer cells are dependent on proline for clonogenicity and tumorigenic potential. These authors profiled a panel of cancer cell lines and found that proline consumption and the expression of enzymes involved (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 23, 2016 Category: Cancer & Oncology Authors: Gemma K. Alderton Tags: Research Highlight Source Type: research
Immunotherapy: Checkpoint barriers
Nature Reviews Cancer 16, 678 (2016).
doi:10.1038/nrc.2016.118
Author: Anna Dart
Two studies have uncovered genetic determinants that shape the response of patients with melanoma to anti-cytotoxic T lymphocyte associated antigen 4 (CTLA4) therapy. Using whole-genome sequencing, these studies identified recurrent mutations that could predict response. Riaz et al. found that mutations in SERPINB3 (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 23, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Tumour metabolism: Location matters
Nature Reviews Cancer 16, 678 (2016).
doi:10.1038/nrc.2016.117
Author: Anna Dart
Glutamine is heavily consumed by tumours. Yet, the regional effects of glutamine deprivation within tumours are unknown. Pan et al. show that low glutamine in the tumour core results in increased histone hypermethylation through a decrease inα-ketoglutarate levels. Depleted glutamine-mediated histone hypermethylation causes cellular (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 23, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Gap junctions and cancer: communicating for 50 years
Nature Reviews Cancer 16, 775 (2016).
doi:10.1038/nrc.2016.105
Authors: Trond Aasen, Marc Mesnil, Christian C. Naus, Paul D. Lampe & Dale W. Laird
Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis that loss of direct intercellular communication is commonly associated with cancer onset and progression. Subsequent studies linked this phenomenon to gap junctions composed of connexin proteins. Although many studies support (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 20, 2016 Category: Cancer & Oncology Authors: Trond Aasen Marc Mesnil Christian C. Naus Paul D. Lampe Dale W. Laird Tags: Perspectives Source Type: research
