Hereditary breast and ovarian cancer: new genes in confined pathways
Nature Reviews Cancer 16, 599 (2016).
doi:10.1038/nrc.2016.72
Authors: Finn Cilius Nielsen, Thomas van Overeem Hansen & Claus Storgaard Sørensen
Genetic abnormalities in the DNA repair genes BRCA1 and BRCA2 predispose to hereditary breast and ovarian cancer (HBOC). However, only approximately 25% of cases of HBOC can be ascribed to BRCA1 and BRCA2 mutations. Recently, exome sequencing has uncovered substantial locus (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 11, 2016 Category: Cancer & Oncology Authors: Finn Cilius Nielsen Thomas van Overeem Hansen Claus Storgaard S ørensen Tags: Review Source Type: research
Chemotherapy: Putting tumours on a diet
Nature Reviews Cancer 16, 549 (2016).
doi:10.1038/nrc.2016.90
Author: Sarah Seton-Rogers
Two papers show that specific diets or pharmacological agents that mimic fasting inhibit tumour growth in combination with chemotherapy through effects on the immune system. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 11, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Resistance: How to resist immunotherapy
Nature Reviews Cancer 16, 550 (2016).
doi:10.1038/nrc.2016.88
Author: M. Teresa Villanueva
Acquired resistance to programmed cell death 1 blockade in patients with melanoma is associated with defects in the pathways involved in interferon-receptor signalling. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 4, 2016 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
Metastasis: Setting up a new home
Nature Reviews Cancer 16, 550 (2016).
doi:10.1038/nrc.2016.86
Author: Anna Dart
In response to tumour-derived signals, fibroblastic reticular cells within tumour-draining lymph nodes acquire a unique gene signature which in turn disrupts the composition and localization of lymph node immune cell populations. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - August 4, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
From Krebs to clinic: glutamine metabolism to cancer therapy
Nature Reviews Cancer 16, 619 (2016).
doi:10.1038/nrc.2016.71
Authors: Brian J. Altman, Zachary E. Stine & Chi V. Dang
The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - July 28, 2016 Category: Cancer & Oncology Authors: Brian J. Altman Zachary E. Stine Chi V. Dang Tags: Review Source Type: research
The genetics and mechanisms of T cell acute lymphoblastic leukaemia
Nature Reviews Cancer 16, 494 (2016).
doi:10.1038/nrc.2016.63
Authors: Laura Belver & Adolfo Ferrando
T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy derived from early T cell progenitors. In recent years genomic and transcriptomic studies have uncovered major oncogenic and tumour suppressor pathways involved in T-ALL transformation and identified distinct biological groups associated with prognosis. An (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - July 24, 2016 Category: Cancer & Oncology Authors: Laura Belver Adolfo Ferrando Tags: Review Source Type: research
Pancreatic cancer: Dodging immunosuppression
Nature Reviews Cancer 16, 480 (2016).
doi:10.1038/nrc.2016.80
Author: Sarah Seton-Rogers
Jiang et al. show that inhibition of focal adhesion kinase (FAK) reduces immunosuppression and fibrosis in pancreatic ductal adenocarcinoma (PDAC) and can improve the efficacy of both chemotherapy and immunotherapy in PDAC mouse models. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - July 24, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Pancreatic cancer biology and genetics from an evolutionary perspective
Nature Reviews Cancer 16, 553 (2016).
doi:10.1038/nrc.2016.66
Authors: Alvin Makohon-Moore & Christine A. Iacobuzio-Donahue
Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma (hereafter referred to as pancreatic cancer) is a particularly robust example of this phenomenon. Genomic features indicate that pancreatic cancer cells are selected for (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - July 21, 2016 Category: Cancer & Oncology Authors: Alvin Makohon-Moore Christine A. Iacobuzio-Donahue Tags: Review Source Type: research
Aurora-A — A guardian of poles
Aurora-A — A guardian of poles
Nature Reviews Cancer 5, 42 (2005). doi:10.1038/nrc1526
Authors: Tomotoshi Marumoto, Dongwei Zhang
& Hideyuki Saya (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - July 21, 2016 Category: Cancer & Oncology Authors: Tomotoshi Marumoto Dongwei Zhang Hideyuki Saya Tags: Review Source Type: research
Tumour suppressors: The dark side of p21
Nature Reviews Cancer 16, 481 (2016).
doi:10.1038/nrc.2016.78
Author: Eytan Zlotorynski
Whereas activation of p21 by p53 causes G1 cell cycle arrest, p53-independent expression of p21 can cause deregulation of DNA replication and genomic instability. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - July 14, 2016 Category: Cancer & Oncology Authors: Eytan Zlotorynski Tags: Research Highlight Source Type: research
Genetics: Acute myeloid leukaemia: driving the driver
Nature Reviews Cancer 16, 479 (2016).
doi:10.1038/nrc.2016.75
Author: M. Teresa Villanueva
Papaemmanuil et al. have described new mutations that drive acute myeloid leukaemia and classify the disease in distinct subgroups associated with different diagnostic features and clinical outcomes (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - July 14, 2016 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
Biomarker development in the precision medicine era: lung cancer as a case study
Nature Reviews Cancer 16, 525 (2016).
doi:10.1038/nrc.2016.56
Authors: Ashley J. Vargas & Curtis C. Harris
Precision medicine relies on validated biomarkers with which to better classify patients by their probable disease risk, prognosis and/or response to treatment. Although affordable 'omics'-based technology has enabled faster identification of putative biomarkers, the validation of biomarkers is still stymied by low statistical power and (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - July 7, 2016 Category: Cancer & Oncology Authors: Ashley J. Vargas Curtis C. Harris Tags: Review Source Type: research
Wildlife cancer: Cancer mussels in
Nature Reviews Cancer 16, 480 (2016).
doi:10.1038/nrc.2016.74
Author: Anna Dart
The identification of multiple independent cancer lineages in multiple bivalve species makes transmissible cancers a common event, not exclusively restricted to the species of origin. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - July 7, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
A fate worse than death: apoptosis as an oncogenic process
Nature Reviews Cancer 16, 539 (2016).
doi:10.1038/nrc.2016.58
Authors: Gabriel Ichim & Stephen W. G. Tait
Apoptotic cell death is widely considered a positive process that both prevents and treats cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also cause unwanted effects that may even promote cancer. In this Opinion article we highlight some of the ways by which (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - June 30, 2016 Category: Cancer & Oncology Authors: Gabriel Ichim Stephen W. G. Tait Tags: Perspectives Source Type: research
The role of enhancers in cancer
Nature Reviews Cancer 16, 483 (2016).
doi:10.1038/nrc.2016.62
Authors: Inderpreet Sur & Jussi Taipale
Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their most important functions is the integration of extracellular signals with intracellular cell fate information to generate cell type-specific transcriptional responses. Mutations occurring in cancer often misregulate enhancers that normally control (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - June 30, 2016 Category: Cancer & Oncology Authors: Inderpreet Sur Jussi Taipale Tags: Review Source Type: research
