From Krebs to clinic: glutamine metabolism to cancer therapy
Nature Reviews Cancer 16, 749 (2016).
doi:10.1038/nrc.2016.114
Author: Brian J. Altman, Zachary E. Stine & Chi V. Dang
Nature Reviews Cancer16, 619–534 (2016)On page 619 of the above article tyrosine was incorrectly referred to as an essential amino acid; this has now been corrected to tryptophan. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 13, 2016 Category: Cancer & Oncology Authors: Brian J. Altman Zachary E. Stine Chi V. Dang Tags: Corrigendum Source Type: research
Cell differentiation: Pushing differentiation
Nature Reviews Cancer 16, 678 (2016).
doi:10.1038/nrc.2016.110
Author: M. Teresa Villanueva
Cell differentiation blockade in the early stages of AML can be overcome by inhibiting dihydroorotate dehydrogenase (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 13, 2016 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
Tumour metabolism: Building up and breaking down fatty acids
Nature Reviews Cancer 16, 677 (2016).
doi:10.1038/nrc.2016.111
Author: Sarah Seton-Rogers
Two studies have looked at the roles of fatty acid synthesis and oxidation, and their therapeutic potential, in cancer. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 13, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Tumour metabolism: Lactic acid: not just a waste product?
Nature Reviews Cancer 16, 676 (2016).
doi:10.1038/nrc.2016.109
Author: Anna Dart
Brand and colleagues show that increased tumour lactate dehydrogenase A (LDHA)-mediated lactic acid production dampens activation and cytokine production of infiltrating T and natural killer (NK) cells allowing tumours to escape immune detection and promoting tumour growth. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - October 6, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Epstein –Barr virus: more than 50 years old and still providing surprises
Nature Reviews Cancer 16, 789 (2016).
doi:10.1038/nrc.2016.92
Authors: Lawrence S. Young, Lee Fah Yap & Paul G. Murray
It is more than 50 years since the Epstein–Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 29, 2016 Category: Cancer & Oncology Authors: Lawrence S. Young Lee Fah Yap Paul G. Murray Tags: Perspectives Source Type: research
Mouse models in oncoimmunology
Nature Reviews Cancer 16, 759 (2016).
doi:10.1038/nrc.2016.91
Authors: Laurence Zitvogel, Jonathan M. Pitt, Romain Daillère, Mark J. Smyth & Guido Kroemer
Fundamental cancer research and the development of efficacious antineoplastic treatments both rely on experimental systems in which the relationship between malignant cells and immune cells can be studied. Mouse models of transplantable, carcinogen-induced or genetically engineered malignancies — each with their specific advantages and difficulties (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 29, 2016 Category: Cancer & Oncology Authors: Laurence Zitvogel Jonathan M. Pitt Romain Daill ère Mark J. Smyth Guido Kroemer Tags: Review Source Type: research
Tumour metabolism: Reflecting their origins
Nature Reviews Cancer 16, 676 (2016).
doi:10.1038/nrc.2016.106
Author: Sarah Seton-Rogers
Mayers, Torrence et al. show that lung tumours driven by oncogenic KRAS and loss of p53 depend on branched-chain amino acid metabolism, whereas pancreatic tumours driven by the same genetic defects do not. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 29, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Tumour metabolism: Translating the undruggable target
Nature Reviews Cancer 16, 675 (2016).
doi:10.1038/nrc.2016.107
Author: Anna Dart
Three studies demonstrate the preclinical potential of a novel class of hypoxia-inducible factor 2α (HIF2α) antagonists in the treatment of von Hippel–Lindau (pVHL)-deficient clear cell renal cell carcinoma. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 29, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
Nature Reviews Cancer 16, 803 (2016).
doi:10.1038/nrc.2016.83
Authors: Itys Comet, Eva M. Riising, Benjamin Leblanc & Kristian Helin
Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive complex 2 (PRC2), has attracted broad research attention in the past few years because of its involvement in the development and maintenance of many types of cancer and the use of specific EZH2 (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 22, 2016 Category: Cancer & Oncology Authors: Itys Comet Eva M. Riising Benjamin Leblanc Kristian Helin Tags: Perspectives Source Type: research
The multifaceted roles of fatty acid synthesis in cancer
Nature Reviews Cancer 16, 732 (2016).
doi:10.1038/nrc.2016.89
Authors: Florian Röhrig & Almut Schulze
Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular process that converts nutrients into metabolic intermediates for membrane biosynthesis, energy storage and the generation of signalling molecules. This Review explores how different aspects of FA synthesis promote tumorigenesis and tumour (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 22, 2016 Category: Cancer & Oncology Authors: Florian R öhrig Almut Schulze Tags: Review Source Type: research
Altered metabolite levels in cancer: implications for tumour biology and cancer therapy
Nature Reviews Cancer 16, 680 (2016).
doi:10.1038/nrc.2016.85
Authors: Lucas B. Sullivan, Dan Y. Gui & Matthew G. Vander Heiden
Altered cell metabolism is a characteristic feature of many cancers. Aside from well-described changes in nutrient consumption and waste excretion, altered cancer cell metabolism also results in changes to intracellular metabolite concentrations. Increased levels of metabolites that result directly from genetic mutations and cancer-associated modifications (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 22, 2016 Category: Cancer & Oncology Authors: Lucas B. Sullivan Dan Y. Gui Matthew G. Vander Heiden Tags: Review Source Type: research
Oxygen availability and metabolic adaptations
Nature Reviews Cancer 16, 663 (2016).
doi:10.1038/nrc.2016.84
Authors: Michael S. Nakazawa, Brian Keith & M. Celeste Simon
Oxygen availability, along with the abundance of nutrients (such as glucose, glutamine, lipids and albumin), fluctuates significantly during tumour evolution and the recruitment of blood vessels, leukocytes and reactive fibroblasts to complex tumour microenvironments. As such, hypoxia and concomitant nutrient scarcity affect large gene expression (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 22, 2016 Category: Cancer & Oncology Authors: Michael S. Nakazawa Brian Keith M. Celeste Simon Tags: Review Source Type: research
Genetics: Transcribing for the enemy
Nature Reviews Cancer 16, 617 (2016).
doi:10.1038/nrc.2016.104
Author: M. Teresa Villanueva
Clark et al. carried out genomic analyses of 775 meningiomas and found recurrent mutations in POLR2A, which encodes the catalytic subunit of RNA polymerase II, an essential enzyme that mediates the transcription of all protein-coding genes in eukaryotic cells. Mutant POLR2A allows (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 22, 2016 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
Tumour evolution: Evolving resistance in Tasmanian devils
Nature Reviews Cancer 16, 617 (2016).
doi:10.1038/nrc.2016.103
Author: Gemma K. Alderton
Devil facial tumour disease (DFTD) is a transmissable cancer that affects Tasmanian devils and has substantially depleted their population, rasing concern that the species faces extinction. However, a new study offers some hope. Epstein et al. report that three populations of Tasmanian devil are (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 22, 2016 Category: Cancer & Oncology Authors: Gemma K. Alderton Tags: Research Highlight Source Type: research
Tumour metabolism: Functions of fumarate
Nature Reviews Cancer 16, 617 (2016).
doi:10.1038/nrc.2016.102
Author: Sarah Seton-Rogers
Sciacovelli et al. find that the higher levels of intracellular fumarate that result from loss of fumarate hydratase (FH), which causes hereditary leiomyomatosis and renal cell carcinoma (HLRCC), promotes epithelial-to-mesenchymal transition (EMT). Fumarate inhibits tet methylcytosine dioxygenase (TET) family enzymes, and the (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 22, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
