Precision diagnostics: moving towards protein biomarker signatures of clinical utility in cancer
Nature Reviews Cancer 17, 199 (2017).
doi:10.1038/nrc.2016.153
Author: Carl A. K. Borrebaeck
Interest in precision diagnostics has been fuelled by the concept that early detection of cancer would benefit patients; that is, if detected early, more tumours should be resectable and treatment more efficacious. Serum contains massive amounts of potentially diagnostic information, and affinity proteomics has risen (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 2, 2017 Category: Cancer & Oncology Authors: Carl A. K. Borrebaeck Tags: Perspectives Source Type: research
Notch as a tumour suppressor
Nature Reviews Cancer 17, 145 (2017).
doi:10.1038/nrc.2016.145
Authors: Craig S. Nowell & Freddy Radtke
The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recent decades has revealed how the role of Notch (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 2, 2017 Category: Cancer & Oncology Authors: Craig S. Nowell Freddy Radtke Tags: Review Source Type: research
SUMO and the robustness of cancer
Nature Reviews Cancer 17, 184 (2017).
doi:10.1038/nrc.2016.143
Authors: Jacob-Sebastian Seeler & Anne Dejean
Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed sumoylation, is an important mechanism in cellular responses to stress and one that appears to be upregulated in many cancers. Here, we examine the role of sumoylation in tumorigenesis as a possibly necessary safeguard that protects (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 29, 2017 Category: Cancer & Oncology Authors: Jacob-Sebastian Seeler Anne Dejean Tags: Review Source Type: research
Cell cycle proteins as promising targets in cancer therapy
Nature Reviews Cancer 17, 93 (2017).
doi:10.1038/nrc.2016.138
Authors: Tobias Otto & Piotr Sicinski
Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant activity of various cell cycle proteins. Therefore, cell cycle regulators are considered attractive targets in cancer therapy. Intriguingly, animal models demonstrate that some of these proteins are not essential for proliferation of non-transformed cells (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 26, 2017 Category: Cancer & Oncology Authors: Tobias Otto Piotr Sicinski Tags: Review Source Type: research
Tumour metabolism: Packed full of protein!
Nature Reviews Cancer 17, 77 (2017).
doi:10.1038/nrc.2017.2
Author: Anna Dart
Davidson et al. used an implantable microdevice to show that pancreatic tumours in vivo catabolize proteins in their local environment, by macropinocytosis, to derive amino acids for cell growth. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 26, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Metastasis: The fat controller
Nature Reviews Cancer 17, 76 (2017).
doi:10.1038/nrc.2017.3
Author: M. Teresa Villanueva
Salvador Aznar Benitah and colleagues have identified a subpopulation of cells with high metastatic potential that express high levels of the fatty acid receptor CD36 in human oral carcinoma samples. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 26, 2017 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
Oncogenes: Coping with stress
Nature Reviews Cancer 17, 76 (2017).
doi:10.1038/nrc.2017.1
Author: Sarah Seton-Rogers
Grabocka and Bar-Sagi have shown that cells expressing mutant KRAS upregulate SGs in response to stress, and that this enhances the survival of both KRAS-mutant and wild-type cells. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 26, 2017 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Metastasis: Planting metastasis early
Nature Reviews Cancer 17, 75 (2017).
doi:10.1038/nrc.2017.4
Author: Gemma K. Alderton
Two papers demonstrate that early disseminated cancer cells (DCCs) from HER2+ breast cancer are more likely to seed metastasis than those from established tumours. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 26, 2017 Category: Cancer & Oncology Authors: Gemma K. Alderton Tags: Research Highlight Source Type: research
Interrogating open issues in cancer precision medicine with patient-derived xenografts
Nature Reviews Cancer 17, 254 (2017).
doi:10.1038/nrc.2016.140
Authors: Annette T. Byrne, Denis G. Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas, Andrew V. Biankin, Alejandra Bruna, Eva Budinská, Carlos Caldas, David K. Chang, Robert B. Clarke, Hans Clevers, George Coukos, Virginie Dangles-Marie, S. Gail Eckhardt, Eva Gonzalez-Suarez, Els Hermans, Manuel Hidalgo, Monika A. Jarzabek, Steven de Jong, Jos Jonkers, Kristel Kemper, Luisa Lanfrancone, Gunhild Mari Mælandsmo, Elisabetta Marangoni, Jean-Christophe Marine, Enzo Medico, Jens Henrik Norum, Héctor G. Palmer, Dani...
Source: Nature Reviews Cancer - January 20, 2017 Category: Cancer & Oncology Authors: Annette T. Byrne Denis G. Alf érez Fr édéric Amant Daniela Annibali Joaqu ín Arribas Andrew V. Biankin Alejandra Bruna Eva Budinsk á Carlos Caldas David K. Chang Robert B. Clarke Hans Clevers George Coukos Virginie Dangles-Marie S. Gail Eckhardt Eva Tags: Perspectives Source Type: research
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
Nature Reviews Cancer 17, 79 (2017).
doi:10.1038/nrc.2016.126
Authors: Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar & Josep Tabernero
Critical driver genomic events in colorectal cancer have been shown to affect the response to targeted agents that were initially developed under the 'one gene, one drug' paradigm of precision medicine. Our current knowledge of the complexity of the cancer genome, clonal evolution patterns under (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 3, 2017 Category: Cancer & Oncology Authors: Rodrigo Dienstmann Louis Vermeulen Justin Guinney Scott Kopetz Sabine Tejpar Josep Tabernero Tags: Review Source Type: research
Cancer genetics: X-inactivation and cancer incidence
Nature Reviews Cancer 17, 3 (2017).
doi:10.1038/nrc.2016.152
Author: Sarah Seton-Rogers
Males have a higher risk than females of developing many cancers but the reasons for this disparity are unclear. Dunford et al. analysed exome sequences of 4,126 tumours across 21 cancer types and identified some tumour suppressor genes on the X chromosome that escape (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 20, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Chemotherapy: Less is more
Nature Reviews Cancer 17, 3 (2017).
doi:10.1038/nrc.2016.151
Author: Anna Dart
In response to maximum tolerated doses of chemotherapy, Chan et al. found that cancer-associated fibroblasts are activated through increased activity of signal transducer and activator of transcription 1 (STAT1) and nuclear factor-κB (NF-κB), leading to elevated levels and release of ELR+ chemokines. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 20, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Leukaemia: Don't let sleeping cells lie
Nature Reviews Cancer 17, 3 (2017).
doi:10.1038/nrc.2016.150
Author: M. Teresa Villanueva
In many patients with acute lymphoblastic leukaemia (ALL), most cells respond to chemotherapy but a minority show resistance and cause relapse with poor outcome. Using patient-derived xenograft models, Ebinger et al. identified a subpopulation of resistant and relapse-inducing cells with long-term dormancy and stemness (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 20, 2016 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
Tumour-Initiating cells: The cell that rocks the tumour
Nature Reviews Cancer 17, 3 (2017).
doi:10.1038/nrc.2016.149
Author: M. Teresa Villanueva
Latil et al. have shown that the cell of origin of squamous cell carcinomas (SCCs) controls epithelial-to-mesenchymal transition (EMT) and aggressiveness of these tumours. SCCs derived from hair follicles are much more prone to undergo EMT and have more metastatic potential compared with SCCs (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 20, 2016 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
That gut feeling
Nature Reviews Cancer 17, 74 (2017).
doi:10.1038/nrc.2016.147
Author: Anna Dart
Tumour microenvironment (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 15, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Correction Source Type: research
