Lymphoma: Now you see it...
Nature Reviews Cancer 17, 2 (2017).
doi:10.1038/nrc.2016.146
Author: Safia Danovi
Scherer et al. show that analysis of circulating tumour DNA can provide prognostic information and predict relapse in patients with diffuse large B-cell lymphoma. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 15, 2016 Category: Cancer & Oncology Authors: Safia Danovi Tags: Research Highlight Source Type: research
The recurrent architecture of tumour initiation, progression and drug sensitivity
Nature Reviews Cancer 17, 116 (2017).
doi:10.1038/nrc.2016.124
Authors: Andrea Califano & Mariano J. Alvarez
Recent studies across multiple tumour types are starting to reveal a recurrent regulatory architecture in which genomic alterations cluster upstream of functional master regulator (MR) proteins, the aberrant activity of which is both necessary and sufficient to maintain tumour cell state. These proteins form small, (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 14, 2016 Category: Cancer & Oncology Authors: Andrea Califano Mariano J. Alvarez Tags: Perspectives Source Type: research
TIMPs: versatile extracellular regulators in cancer
Nature Reviews Cancer 17, 38 (2017).
doi:10.1038/nrc.2016.115
Authors: Hartland W. Jackson, Virginie Defamie, Paul Waterhouse & Rama Khokha
A compelling long-term goal of cancer biology is to understand the crucial players during tumorigenesis in order to develop new interventions. Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 8, 2016 Category: Cancer & Oncology Authors: Hartland W. Jackson Virginie Defamie Paul Waterhouse Rama Khokha Tags: Review Source Type: research
Immunotherapy: Switching off immune suppression
Nature Reviews Cancer 17, 1 (2017).
doi:10.1038/nrc.2016.144
Author: Sarah Seton-Rogers
Two papers have shown in mouse tumour models that targeting PI3Kγ in myeloid cells can reduce immune suppression and increase the efficacy of immune checkpoint inhibitors. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 8, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Cancer cell motility: lessons from migration in confined spaces
Nature Reviews Cancer 17, 131 (2017).
doi:10.1038/nrc.2016.123
Authors: Colin D. Paul, Panagiotis Mistriotis & Konstantinos Konstantopoulos
Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 1, 2016 Category: Cancer & Oncology Authors: Colin D. Paul Panagiotis Mistriotis Konstantinos Konstantopoulos Tags: Perspectives Source Type: research
Gap junctions and cancer: communicating for 50 years
Nature Reviews Cancer 17, 74 (2017).
doi:10.1038/nrc.2016.142
Author: Trond Aasen, Marc Mesnil, Christian C. Naus, Paul D. Lampe & Dale W. Laird
Nature Reviews Cancer16, 775–78810.1038/nrc.2016.105(2016)On page 779 of the above article there were errors in line 7 of Table 1. The carcinogen used in the mouse model was DEN and the outcome was increased liver tumours in (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 1, 2016 Category: Cancer & Oncology Authors: Trond Aasen Marc Mesnil Christian C. Naus Paul D. Lampe Dale W. Laird Tags: Corrigendum Source Type: research
Cell migration: Caged for protection
Nature Reviews Cancer 17, 2 (2017).
doi:10.1038/nrc.2016.141
Author: Anna Dart
Skau et al. demonstrate that the actin nucleating protein FMN2 generates a perinuclear actin and focal adhesion-based structure to protect the nucleus from damage during cell migration through confining 3D microenvironments. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 1, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
The disparate origins of ovarian cancers: pathogenesis and prevention strategies
Nature Reviews Cancer 17, 65 (2017).
doi:10.1038/nrc.2016.113
Authors: Anthony N. Karnezis, Kathleen R. Cho, C. Blake Gilks, Celeste Leigh Pearce & David G. Huntsman
Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 24, 2016 Category: Cancer & Oncology Authors: Anthony N. Karnezis Kathleen R. Cho C. Blake Gilks Celeste Leigh Pearce David G. Huntsman Tags: Perspectives Source Type: research
Deciphering the divergent roles of progestogens in breast cancer
Nature Reviews Cancer 17, 54 (2017).
doi:10.1038/nrc.2016.116
Authors: Jason S. Carroll, Theresa E. Hickey, Gerard A. Tarulli, Michael Williams & Wayne D. Tilley
Most breast cancers are driven by oestrogen receptor-α. Anti-oestrogenic drugs are the standard treatment for these breast cancers; however, treatment resistance is common, necessitating new therapeutic strategies. Recent preclinical and historical clinical studies support the use of progestogens to activate the progesterone receptor (PR) in (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 24, 2016 Category: Cancer & Oncology Authors: Jason S. Carroll Theresa E. Hickey Gerard A. Tarulli Michael Williams Wayne D. Tilley Tags: Perspectives Source Type: research
Immunotherapy: Powerful combinations
Nature Reviews Cancer 16, 757 (2016).
doi:10.1038/nrc.2016.136
Author: Sarah Seton-Rogers
Immunotherapies are not effective in all cancer patients, likely due in part to immunosuppressive networks in advanced tumours. Moynihan et al. found that combination immunotherapy consisting of four components (a tumour antigen-targeting antibody, extended half-life recombinant interleukin-2, a programmed cell death protein 1 (PD1) (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Tumour immunology: The consequences of concomitant challenges
Nature Reviews Cancer 16, 757 (2016).
doi:10.1038/nrc.2016.135
Author: Sarah Seton-Rogers
Kohlhapp et al. found that acute influenza infection accelerates cancer-specific death of immunocompetent mice injected with B16 melanoma cells. Infection caused CD8+ T cells to move from the tumour to the site of infection, thus allowing increased tumour growth; this could be (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2016 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Tumour metabolism: When metabolic and epigenetic states converge
Nature Reviews Cancer 16, 757 (2016).
doi:10.1038/nrc.2016.134
Author: Anna Dart
Metabolic and epigenetic states in cells can be linked when intermediary metabolism generates substrates for chromatin regulation. Kottakis et al. have found that synergistic liver kinase B1 (LKB1) loss and KRAS activation can promote mTOR-mediated serine biosynthesis pathway dependency during pancreatic tumorigenesis. The subsequent (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Metastasis: Caught in a trap
Nature Reviews Cancer 16, 757 (2016).
doi:10.1038/nrc.2016.133
Author: Anna Dart
Neutrophils can capture and kill pathogens by releasing DNA and associated proteolytic enzymes into the extracellular space, forming structures known as neutrophil extracellular traps (NETs). Park et al. have shown that in the absence of infection, metastatic breast cancer cells can stimulate neutrophils to (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Anticancer drugs: Breaking up a pro-survival interaction
Nature Reviews Cancer 16, 754 (2016).
doi:10.1038/nrc.2016.139
Author: Alexandra Flemming
A paper in Nature describes a highly specific and potent small molecule inhibitor of MCL1 that has single-agent activity and good tolerability in several cancer models. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2016 Category: Cancer & Oncology Authors: Alexandra Flemming Tags: Research Highlight Source Type: research
Tumour metabolism: RED(D1) or dead
Nature Reviews Cancer 16, 754 (2016).
doi:10.1038/nrc.2016.132
Author: Nicola McCarthy
Mathias Wenes and colleagues have studied metabolic changes in tumour associated macrophages (TAMs) and found that specific alterations of mTOR regulation through regulated in development and DNA damage response 1 (REDD1) results in defective blood vessel formation and increased metastasis. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2016 Category: Cancer & Oncology Authors: Nicola McCarthy Tags: Research Highlight Source Type: research
