Deciphering the divergent roles of progestogens in breast cancer

Nature Reviews Cancer 17, 54 (2017). doi:10.1038/nrc.2016.116 Authors: Jason S. Carroll, Theresa E. Hickey, Gerard A. Tarulli, Michael Williams & Wayne D. Tilley Most breast cancers are driven by oestrogen receptor-α. Anti-oestrogenic drugs are the standard treatment for these breast cancers; however, treatment resistance is common, necessitating new therapeutic strategies. Recent preclinical and historical clinical studies support the use of progestogens to activate the progesterone receptor (PR) in
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Perspectives Source Type: research