TIMPs: versatile extracellular regulators in cancer

Nature Reviews Cancer 17, 38 (2017). doi:10.1038/nrc.2016.115 Authors: Hartland W. Jackson, Virginie Defamie, Paul Waterhouse & Rama Khokha A compelling long-term goal of cancer biology is to understand the crucial players during tumorigenesis in order to develop new interventions. Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research