The recurrent architecture of tumour initiation, progression and drug sensitivity

Nature Reviews Cancer 17, 116 (2017). doi:10.1038/nrc.2016.124 Authors: Andrea Califano & Mariano J. Alvarez Recent studies across multiple tumour types are starting to reveal a recurrent regulatory architecture in which genomic alterations cluster upstream of functional master regulator (MR) proteins, the aberrant activity of which is both necessary and sufficient to maintain tumour cell state. These proteins form small,
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Perspectives Source Type: research