The recurrent architecture of tumour initiation, progression and drug sensitivity
Nature Reviews Cancer 17, 116 (2017).
doi:10.1038/nrc.2016.124
Authors: Andrea Califano & Mariano J. Alvarez
Recent studies across multiple tumour types are starting to reveal a recurrent regulatory architecture in which genomic alterations cluster upstream of functional master regulator (MR) proteins, the aberrant activity of which is both necessary and sufficient to maintain tumour cell state. These proteins form small,
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Andrea Califano Mariano J. Alvarez Tags: Perspectives Source Type: research