New frontiers in translational control of the cancer genome
Nature Reviews Cancer 17, 332 (2017).
doi:10.1038/nrc.2017.30
Author: Morgan L. Truitt & Davide Ruggero
Nature Reviews Cancer16, 288–30410.1038/nrc.2016.27 (2016)In this Review, in Figure 1, for both the figure and figure legend 'eIF4B' was incorrectly labelled as 'eIF2B'. The paper has been corrected online. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 24, 2017 Category: Cancer & Oncology Authors: Morgan L. Truitt Davide Ruggero Tags: Corrigendum Source Type: research
Tumour Suppressors: Following the clues of cancer-resistant tissues
Nature Reviews Cancer 17, 269 (2017).
doi:10.1038/nrc.2017.29
Author: Sarah Seton-Rogers
Using gene expression analyses of cancer-resistant differentiated muscle cells, Keckesova et al. identify a mitochondrial protein, lactamase β (LACTB), that affects lipid metabolism and can induce differentiation and suppress proliferation of breast cancer cells in vitro and in vivo. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 24, 2017 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
RNA editing-dependent epitranscriptome diversity in cancer stem cells
Nature Reviews Cancer 17, 381 (2017).
doi:10.1038/nrc.2017.23
Authors: Qingfei Jiang, Leslie A. Crews, Frida Holm & Catriona H. M. Jamieson
Cancer stem cells (CSCs) can regenerate all facets of a tumour as a result of their stem cell-like capacity to self-renew, survive and become dormant in protective microenvironments. CSCs evolve during tumour progression in a manner that conforms to Charles Darwin's principle of natural selection. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 18, 2017 Category: Cancer & Oncology Authors: Qingfei Jiang Leslie A. Crews Frida Holm Catriona H. M. Jamieson Tags: Review Source Type: research
The calcium – cancer signalling nexus
Nature Reviews Cancer 17, 367 (2017).
doi:10.1038/nrc.2017.18
Authors: Gregory R. Monteith, Natalia Prevarskaya & Sarah J. Roberts-Thomson
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific outcomes. Cellular machinery important in tumour progression is often driven or influenced by changes in calcium ions; in some cases this regulation occurs within spatially defined regions. Over the past (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 7, 2017 Category: Cancer & Oncology Authors: Gregory R. Monteith Natalia Prevarskaya Sarah J. Roberts-Thomson Tags: Review Source Type: research
Metastasis: Breaching barriers
Nature Reviews Cancer 17, 270 (2017).
doi:10.1038/nrc.2017.27
Author: Anna Dart
Boire et al. describe a mechanism by which cancer cells can survive and grow in the leptomeninges of the brain by upregulating complement component 3 (C3) to disrupt blood–cerebrospinal fluid barrier function, allowing entry of growth-promoting factors. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 7, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Prospects for combining targeted and conventional cancer therapy with immunotherapy
Nature Reviews Cancer 17, 286 (2017).
doi:10.1038/nrc.2017.17
Authors: Philip Gotwals, Scott Cameron, Daniela Cipolletta, Viviana Cremasco, Adam Crystal, Becker Hewes, Britta Mueller, Sonia Quaratino, Catherine Sabatos-Peyton, Lilli Petruzzelli, Jeffrey A. Engelman & Glenn Dranoff
Over the past 25 years, research in cancer therapeutics has largely focused on two distinct lines of enquiry. In one approach, efforts to understand the underlying cell-autonomous, genetic drivers of tumorigenesis have led to the development of clinically important targeted agents that result in profound, (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 24, 2017 Category: Cancer & Oncology Authors: Philip Gotwals Scott Cameron Daniela Cipolletta Viviana Cremasco Adam Crystal Becker Hewes Britta Mueller Sonia Quaratino Catherine Sabatos-Peyton Lilli Petruzzelli Jeffrey A. Engelman Glenn Dranoff Tags: Review Source Type: research
A chemical probe toolbox for dissecting the cancer epigenome
Nature Reviews Cancer 17, 268 (2017).
doi:10.1038/nrc.2017.26
Author: Jake shortt, Christopher J. Ott, Ricky W. Johnstone & James E. Bradner
Nature Reviews Cancer17, 160–183 (2017)Supplementary information S1–S6 (tables) for this article have been replaced, with several minor errors in the tables and references corrected. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 23, 2017 Category: Cancer & Oncology Authors: Jake shortt Christopher J. Ott Ricky W. Johnstone James E. Bradner Tags: Corrigendum Source Type: research
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
Nature Reviews Cancer 17, 268 (2017).
doi:10.1038/nrc.2017.24
Author: Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar & Josep Tabernero
Nature Reviews Cancer17, 79–92 (2017)In this article a source of grant funding for one of the authors was omitted from the Acknowledgements section. The online version of the article has been corrected to include: “The work of (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 23, 2017 Category: Cancer & Oncology Authors: Rodrigo Dienstmann Louis Vermeulen Justin Guinney Scott Kopetz Sabine Tejpar Josep Tabernero Tags: Corrigendum Source Type: research
Epigenetics: Addicted to reading
Nature Reviews Cancer 17, 207 (2017).
doi:10.1038/nrc.2017.25
Author: Anna Dart
Two papers find that the histone acetylation reader function of the YEATS domain of ENL is required to sustain oncogenic transcriptional programmes for the growth and disease maintenance of acute leukaemias. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 23, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Advances and challenges in targeting FGFR signalling in cancer
Nature Reviews Cancer 17, 318 (2017).
doi:10.1038/nrc.2017.8
Authors: Irina S. Babina & Nicholas C. Turner
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 17, 2017 Category: Cancer & Oncology Authors: Irina S. Babina Nicholas C. Turner Tags: Review Source Type: research
Pre-metastatic niches: organ-specific homes for metastases
Nature Reviews Cancer 17, 302 (2017).
doi:10.1038/nrc.2017.6
Authors: Héctor Peinado, Haiying Zhang, Irina R. Matei, Bruno Costa-Silva, Ayuko Hoshino, Goncalo Rodrigues, Bethan Psaila, Rosandra N. Kaplan, Jacqueline F. Bromberg, Yibin Kang, Mina J. Bissell, Thomas R. Cox, Amato J. Giaccia, Janine T. Erler, Sachie Hiratsuka, Cyrus M. Ghajar & David Lyden
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastas...
Source: Nature Reviews Cancer - March 17, 2017 Category: Cancer & Oncology Authors: H é ctor Peinado Haiying Zhang Irina R. Matei Bruno Costa-Silva Ayuko Hoshino Goncalo Rodrigues Bethan Psaila Rosandra N. Kaplan Jacqueline F. Bromberg Yibin Kang Mina J. Bissell Thomas R. Cox Amato J. Giaccia Janine T. Erler Sachie Hiratsuka Cyrus M. Gh Tags: Review Source Type: research
Microbiota: a key orchestrator of cancer therapy
Nature Reviews Cancer 17, 271 (2017).
doi:10.1038/nrc.2017.13
Authors: Soumen Roy & Giorgio Trinchieri
The microbiota is composed of commensal bacteria and other microorganisms that live on the epithelial barriers of the host. The commensal microbiota is important for the health and survival of the organism. Microbiota influences physiological functions from the maintenance of barrier homeostasis locally to the (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 17, 2017 Category: Cancer & Oncology Authors: Soumen Roy Giorgio Trinchieri Tags: Review Source Type: research
Advances and challenges in targeting FGFR signalling in cancer
Nature Reviews Cancer 17, 318 (2017).
doi:10.1038/nrc.2017.8
Authors: Irina S. Babina & Nicholas C. Turner
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 17, 2017 Category: Cancer & Oncology Authors: Irina S. Babina Nicholas C. Turner Tags: Review Source Type: research
