Advances and challenges in targeting FGFR signalling in cancer
Nature Reviews Cancer 17, 318 (2017).
doi:10.1038/nrc.2017.8
Authors: Irina S. Babina & Nicholas C. Turner
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Irina S. Babina Nicholas C. Turner Tags: Review Source Type: research