Tumour microenvironment: Microbes matter
Nature Reviews Cancer 18, 1 (2018).
doi:10.1038/nrc.2017.120
Author: Anna Dart
The gut microbiome can modulate the clinical response to anti-programmed cell death protein 1 (PD1) immunotherapy in patients with solid tumours. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 8, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Differentiation therapy revisited
Nature Reviews Cancer 18, 117 (2018).
doi:10.1038/nrc.2017.103
Author: Hugues de Thé
The concept of differentiation therapy emerged from the fact that hormones or cytokines may promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells. Its hallmark success has been the treatment of acute promyelocytic leukaemia (APL), a condition that is now highly (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 1, 2017 Category: Cancer & Oncology Authors: Hugues de Th é Tags: Perspectives Source Type: research
Ribosome biogenesis in cancer: new players and therapeutic avenues
Nature Reviews Cancer 18, 51 (2018).
doi:10.1038/nrc.2017.104
Authors: Joffrey Pelletier, George Thomas & Siniša Volarević
The ribosome is a complex molecular machine composed of numerous distinct proteins and nucleic acids and is responsible for protein synthesis in every living cell. Ribosome biogenesis is one of the most multifaceted and energy- demanding processes in biology, involving a large number of assembly (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 1, 2017 Category: Cancer & Oncology Authors: Joffrey Pelletier George Thomas Sini š a Volarevi ć Tags: Perspectives Source Type: research
Immunotherapy: Burning fences
Nature Reviews Cancer 18, 2 (2018).
doi:10.1038/nrc.2017.119
Author: Ulrike Harjes
New research published in Nature now demonstrates that immune checkpoint blockade can alleviate hepatocellular carcinoma progression in patients with nonalcoholic steatohepatitis (NASH) by inhibiting immunosuppressive immunoglobulin A-producing cells in the liver. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - December 1, 2017 Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
Non-coding RNA networks in cancer
Nature Reviews Cancer 18, 5 (2018).
doi:10.1038/nrc.2017.99
Authors: Eleni Anastasiadou, Leni S. Jacob & Frank J. Slack
Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the past decade has altered our perception of ncRNAs from 'junk' transcriptional products to functional regulatory molecules that mediate cellular processes including chromatin remodelling, transcription, post-transcriptional modifications and signal transduction. The networks in (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 24, 2017 Category: Cancer & Oncology Authors: Eleni Anastasiadou Leni S. Jacob Frank J. Slack Tags: Review Source Type: research
Targeting immunosuppressive adenosine in cancer
Nature Reviews Cancer 17, 765 (2017).
doi:10.1038/nrc.2017.110
Author: Dipti Vijayan, Arabella Young, Michele W. L. Teng & Mark J. Smyth
Nature Reviews Cancer17, 709–72410.1038/nrc.2017.86(2017)When the article was initially published online, reference 80 was incorrectly listed in the reference list. This has now been corrected in the print and online versions of the article. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2017 Category: Cancer & Oncology Authors: Dipti Vijayan Arabella Young Michele W. L. Teng Mark J. Smyth Tags: Corrigendum Source Type: research
Tumour biomarkers: A mark is a marker
Nature Reviews Cancer 17, 708 (2017).
doi:10.1038/nrc.2017.115
Author: Ulrike Harjes
Early detection of cancer is crucial to improve prognosis, and circulating tumour DNA (ctDNA) presents a minimally invasive screening tool. In contrast to mutation patterns, DNA methylation patterns in ctDNA resemble that of cancer tissue. Xu et al. showed that ctDNA methylation patterns can (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2017 Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
Leukaemia: Crowd control
Nature Reviews Cancer 17, 708 (2017).
doi:10.1038/nrc.2017.114
Author: Ulrike Harjes
In acute myeloid leukaemia (AML), accumulating leukaemic blasts occupy specialized niches in the bone marrow (BM). However, the extent to which normal haematopoiesis is affected in AML cannot be fully accounted for by this anatomical crowding of the BM. Boyd et al. found that (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2017 Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
Metabolism: Conscious decoupling
Nature Reviews Cancer 17, 708 (2017).
doi:10.1038/nrc.2017.113
Author: Ulrike Harjes
Aerobic metabolism is assumed to rely predominantly on glucose as fuel for the tricarboxylic acid (TCA) cycle and mitochondrial respiration. Hui et al. showed that lactate derived from the circulation can predominantly fuel the TCA cycle in most tissues. They investigated circulatory fluxes of (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2017 Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
Immunotherapy: Rewiring cancer cells
Nature Reviews Cancer 17, 706 (2017).
doi:10.1038/nrc.2017.112
Author: Anna Dart
A modular synthetic RNA-based gene circuit has been developed to program tumour cells to express a combination of immunomodulators to improve the specificity and efficacy of cancer immunotherapy. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 22, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Sphingolipid metabolism in cancer signalling and therapy
Nature Reviews Cancer 18, 33 (2018).
doi:10.1038/nrc.2017.96
Author: Besim Ogretmen
Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-phosphate (S1P), have opposing roles in regulating cancer cell death and survival, respectively, and there have been exciting developments in understanding how sphingolipid metabolism and signalling regulate these processes in response to anticancer therapy. Recent studies (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 17, 2017 Category: Cancer & Oncology Authors: Besim Ogretmen Tags: Review Source Type: research
Small-cell lung cancer: what we know, what we need to know and the path forward
Nature Reviews Cancer 17, 765 (2017).
doi:10.1038/nrc.2017.106
Author: Adi F. Gazdar, Paul A. Bunn & John D. Minna (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2017 Category: Cancer & Oncology Authors: Adi F. Gazdar Paul A. Bunn John D. Minna Tags: Corrigendum Source Type: research
Transport of drugs from blood vessels to tumour tissue
Nature Reviews Cancer 17, 738 (2017).
doi:10.1038/nrc.2017.93
Authors: Mark W. Dewhirst & Timothy W. Secomb
The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue depends on the plasma pharmacokinetics, the structure and function of the tumour vasculature (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2017 Category: Cancer & Oncology Authors: Mark W. Dewhirst Timothy W. Secomb Tags: Review Source Type: research
Tumour angiogenesis: Controlling nerves
Nature Reviews Cancer 17, 708 (2017).
doi:10.1038/nrc.2017.107
Author: Ulrike Harjes
Sympathetic nerves associate with tumours and regulate the tumour microenvironment. How this innervation promotes tumorigenesis is unclear. A new study in Science shows that β-adrenergic signalling controls tumour growth by promoting tumour angiogenesis, through the regulation of vascular metabolism. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2017 Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
Tumour suppressors: Digging deeper into p53's functions
Nature Reviews Cancer 17, 706 (2017).
doi:10.1038/nrc.2017.108
Author: Sarah Seton-Rogers
Mello et al. analysed the effects of various p53 transactivation domain mutants in pancreatic ductal adenocarcinoma and uncovered a crucial tumour-suppressive pathway in which p53 mediates inhibition of the transcriptional co-activator YAP. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - November 10, 2017 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
