Differentiation therapy revisited

Nature Reviews Cancer 18, 117 (2018). doi:10.1038/nrc.2017.103 Author: Hugues de Thé The concept of differentiation therapy emerged from the fact that hormones or cytokines may promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells. Its hallmark success has been the treatment of acute promyelocytic leukaemia (APL), a condition that is now highly
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Perspectives Source Type: research