Pre-metastatic niches: organ-specific homes for metastases
Nature Reviews Cancer 17, 302 (2017).
doi:10.1038/nrc.2017.6
Authors: Héctor Peinado, Haiying Zhang, Irina R. Matei, Bruno Costa-Silva, Ayuko Hoshino, Goncalo Rodrigues, Bethan Psaila, Rosandra N. Kaplan, Jacqueline F. Bromberg, Yibin Kang, Mina J. Bissell, Thomas R. Cox, Amato J. Giaccia, Janine T. Erler, Sachie Hiratsuka, Cyrus M. Ghajar & David Lyden
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastas...
Source: Nature Reviews Cancer - March 17, 2017 Category: Cancer & Oncology Authors: H éctor Peinado Haiying Zhang Irina R. Matei Bruno Costa-Silva Ayuko Hoshino Goncalo Rodrigues Bethan Psaila Rosandra N. Kaplan Jacqueline F. Bromberg Yibin Kang Mina J. Bissell Thomas R. Cox Amato J. Giaccia Janine T. Erler Sachie Hiratsuka Cyrus M. Gha Tags: Review Source Type: research
Microbiota: a key orchestrator of cancer therapy
Nature Reviews Cancer 17, 271 (2017).
doi:10.1038/nrc.2017.13
Authors: Soumen Roy & Giorgio Trinchieri
The microbiota is composed of commensal bacteria and other microorganisms that live on the epithelial barriers of the host. The commensal microbiota is important for the health and survival of the organism. Microbiota influences physiological functions from the maintenance of barrier homeostasis locally to the (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 17, 2017 Category: Cancer & Oncology Authors: Soumen Roy Giorgio Trinchieri Tags: Review Source Type: research
Cancer therapy-induced PAFR ligand expression: any role for caspase activity?
Nature Reviews Cancer 17, 253 (2017).
doi:10.1038/nrc.2017.16
Authors: Gabriel Ichim & Stephen W. G. Tait
Our recent Opinion article discussed the oncogenic effects of engaging apoptosis and their impact on cancer (Nat. Rev. Cancer16, 539–548; 2016). We would like to thank Roger Chammas, Luciana Nogueira de Sousa Andrade and Sonia Jancar for their correspondence on our (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 10, 2017 Category: Cancer & Oncology Authors: Gabriel Ichim Stephen W. G. Tait Tags: Reply Source Type: research
Oncogenic effects of PAFR ligands produced in tumours upon chemotherapy and radiotherapy
Nature Reviews Cancer 17, 253 (2017).
doi:10.1038/nrc.2017.15
Authors: Roger Chammas, Luciana Nogueira de Sousa Andrade & Sonia Jancar
The Opinion article from Gabriel Ichim and Stephen W. G. Tait, 'A fate worse than death: apoptosis as an oncogenic process' (Nat. Rev. Cancer16, 539–548; 2016), highlights intrinsic mechanisms of failure of commonly used cancer therapies that are heavily dependent (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 10, 2017 Category: Cancer & Oncology Authors: Roger Chammas Luciana Nogueira de Sousa Andrade Sonia Jancar Tags: Correspondence Source Type: research
Genomics: A different view of the landscape
Nature Reviews Cancer 17, 206 (2017).
doi:10.1038/nrc.2017.22
Author: Sarah Seton-Rogers
Using data from The Cancer Genome Atlas, Carter et al. find that germline variations can influence tumour sites of origin and somatic mutations. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 10, 2017 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Cell migration: Shall we travel together?
Nature Reviews Cancer 17, 205 (2017).
doi:10.1038/nrc.2017.21
Author: Anna Dart
Mechanical coupling of cancer-associated fibroblasts and cancer cells through a heterotypic E-cadherin–N-cadherin adherens junction promotes cancer cell invasion. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 10, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Tissue-specific tumorigenesis: context matters
Nature Reviews Cancer 17, 239 (2017).
doi:10.1038/nrc.2017.5
Authors: Günter Schneider, Marc Schmidt-Supprian, Roland Rad & Dieter Saur
How can we treat cancer more effectively? Traditionally, tumours from the same anatomical site are treated as one tumour entity. This concept has been challenged by recent breakthroughs in cancer genomics and translational research that have enabled molecular tumour profiling. The identification and validation of (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 3, 2017 Category: Cancer & Oncology Authors: G ünter Schneider Marc Schmidt-Supprian Roland Rad Dieter Saur Tags: Perspectives Source Type: research
Immunotherapy: Engineered T cells for all
Nature Reviews Cancer 17, 206 (2017).
doi:10.1038/nrc.2017.19
Author: Gemma K. Alderton
A report in Science Translational Medicine provides the first example of using universal engineered chimeric antigen receptor (CAR) T cells from human leukocyte antigen (HLA)-mismatched donors. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 3, 2017 Category: Cancer & Oncology Authors: Gemma K. Alderton Tags: Research Highlight Source Type: research
Liquid biopsies come of age: towards implementation of circulating tumour DNA
Nature Reviews Cancer 17, 223 (2017).
doi:10.1038/nrc.2017.7
Authors: Jonathan C. M. Wan, Charles Massie, Javier Garcia-Corbacho, Florent Mouliere, James D. Brenton, Carlos Caldas, Simon Pacey, Richard Baird & Nitzan Rosenfeld
Improvements in genomic and molecular methods are expanding the range of potential applications for circulating tumour DNA (ctDNA), both in a research setting and as a 'liquid biopsy' for cancer management. Proof-of-principle studies have demonstrated the translational potential of ctDNA for prognostication, molecular profiling and (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 24, 2017 Category: Cancer & Oncology Authors: Jonathan C. M. Wan Charles Massie Javier Garcia-Corbacho Florent Mouliere James D. Brenton Carlos Caldas Simon Pacey Richard Baird Nitzan Rosenfeld Tags: Review Source Type: research
Targeting neoantigens to augment antitumour immunity
Nature Reviews Cancer 17, 209 (2017).
doi:10.1038/nrc.2016.154
Authors: Mark Yarchoan, Burles A. Johnson, Eric R. Lutz, Daniel A. Laheru & Elizabeth M. Jaffee
The past decade of cancer research has been marked by a growing appreciation of the role of immunity in cancer. Mutations in the tumour genome can cause tumours to express mutant proteins that are tumour specific and not expressed on normal cells (neoantigens). These neoantigens (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 24, 2017 Category: Cancer & Oncology Authors: Mark Yarchoan Burles A. Johnson Eric R. Lutz Daniel A. Laheru Elizabeth M. Jaffee Tags: Review Source Type: research
A chemical probe toolbox for dissecting the cancer epigenome
Nature Reviews Cancer 17, 160 (2017).
doi:10.1038/nrc.2016.148
Authors: Jake Shortt, Christopher J. Ott, Ricky W. Johnstone & James E. Bradner
Cancer cell hallmarks are underpinned by transcriptional programmes operating in the context of a dynamic and complicit epigenomic environment. Somatic alterations of chromatin modifiers are among the most prevalent cancer perturbations. There is a pressing need for targeted chemical probes to dissect these complex, interconnected (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 22, 2017 Category: Cancer & Oncology Authors: Jake Shortt Christopher J. Ott Ricky W. Johnstone James E. Bradner Tags: Review Source Type: research
Tumorigenesis: Extra! Extra! Read all about it!
Nature Reviews Cancer 17, 143 (2017).
doi:10.1038/nrc.2017.12
Author: Anna Dart
Two papers demonstrate that centrosome amplification can cause cancer in mammals and that a PIDDosome–p53-dependent control mechanism acts to prevent cell proliferation in the presence of extra centrosomes. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 22, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Tumour evolution: Epigenetic and genetic heterogeneity in metastasis
Nature Reviews Cancer 17, 141 (2017).
doi:10.1038/nrc.2017.11
Author: Gemma K. Alderton
How similar are metastases to the primary tumour and other metastases in the same patient? And what does that tell us about the evolution of metastatic ability? Two papers investigated these questions in pancreatic ductal adenocarcinoma (PDAC). (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 22, 2017 Category: Cancer & Oncology Authors: Gemma K. Alderton Tags: Research Highlight Source Type: research
Tumorigenesis: Fitness penalties of aneuploidy
Nature Reviews Cancer 17, 142 (2017).
doi:10.1038/nrc.2017.9
Author: Sarah Seton-Rogers
Sheltzer et al. find that single-chromosome gains can prevent tumorigenesis relative to genetically matched euploid cells, but that these aneuploid cells can evolve over time to have improved fitness. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 9, 2017 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Early detection: The algorithm will see you now
Nature Reviews Cancer 17, 142 (2017).
doi:10.1038/nrc.2017.10
Author: Anna Dart
Esteva et al. have developed an artificial intelligence algorithm which recognises and classifies skin cancers as accurately as specialist clinicians, thereby automating diagnosis. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 9, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
