Metastasis: Staying organized
Nature Reviews Cancer 18, 208 (2018).
doi:10.1038/nrc.2018.20
Author: Sarah Seton-Rogers
A recent study published in Nature Cell Biology has shown that tumour spheres that maintain an inverted epithelial architecture originate from primary colorectal cancers and can collectively invade the peritoneum, initiating metastasis. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 2, 2018 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Drug delivery: DNA nanorobots — seek and destroy
Nature Reviews Cancer 18, 208 (2018).
doi:10.1038/nrc.2018.19
Author: Conor A. Bradley
Li et al. report the development of 'DNA nanorobots' carrying a thrombin protease payload that induce coagulation and necrosis at the tumour site, illustrating their therapeutic potential as drug delivery systems. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - March 2, 2018 Category: Cancer & Oncology Authors: Conor A. Bradley Tags: Research Highlight Source Type: research
Genomic instability: The sting of metastasis
Nature Reviews Cancer 18, 137 (2018).
doi:10.1038/nrc.2018.16
Author: Sarah Seton-Rogers
Data presented by Bakhoum, Ngo et al. suggest that chromosomal instability can promote metastasis through a cGAS–STING-dependent response to cytosolic DNA. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 22, 2018 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Tumour microenvironment: Fibroblast subtype provides niche for cancer stem cells
Nature Reviews Cancer 18, 136 (2018).
doi:10.1038/nrc.2018.18
Author: Megan Cully
A subset of cancer-associated firboblasts, defined by the presence of the cell surface markers CD10 and GPR77, promotes tumour formation and chemoresistance by providing a niche for cancer stem cells. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 22, 2018 Category: Cancer & Oncology Authors: Megan Cully Tags: Research Highlight Source Type: research
Breast cancer: Staying silent
Nature Reviews Cancer 18, 136 (2018).
doi:10.1038/nrc.2018.17
Author: Ulrike Harjes
Mitogen- and stress-activated kinase 1 (MSK1) has been identified as an epigenetic modulator of luminal gene expression in breast cancer, maintaining latency of bone micrometastases. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 22, 2018 Category: Cancer & Oncology Authors: Ulrike Harjes Tags: Research Highlight Source Type: research
Using immunotherapy to boost the abscopal effect
Nature Reviews Cancer 18, 313 (2018).
doi:10.1038/nrc.2018.6
Authors: Wilfred Ngwa, Omoruyi Credit Irabor, Jonathan D. Schoenfeld, Jürgen Hesser, Sandra Demaria & Silvia C. Formenti
More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression of metastatic cancer at distant sites that are not irradiated was described and called the abscopal effect (from 'ab scopus', that is, away from the target). The abscopal effect (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 16, 2018 Category: Cancer & Oncology Authors: Wilfred Ngwa Omoruyi Credit Irabor Jonathan D. Schoenfeld J ü rgen Hesser Sandra Demaria Silvia C. Formenti Tags: Perspectives Source Type: research
Gut microbiota injury in allogeneic haematopoietic stem cell transplantation
Nature Reviews Cancer 18, 283 (2018).
doi:10.1038/nrc.2018.10
Authors: Yusuke Shono & Marcel R. M. van den Brink
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is considered to be the strongest curative immunotherapy for various malignancies (primarily, but not limited to, haematologic malignancies). However, application of allo-HSCT is limited owing to its life-threatening major complications, such as graft-versus-host disease (GVHD), relapse and infections. Recent (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 16, 2018 Category: Cancer & Oncology Authors: Yusuke Shono Marcel R. M. van den Brink Tags: Review Source Type: research
From genetics to the clinic: a translational perspective on follicular lymphoma
Nature Reviews Cancer 18, 224 (2018).
doi:10.1038/nrc.2017.127
Authors: Sarah Huet, Pierre Sujobert & Gilles Salles
Follicular lymphoma (FL) is the most frequent indolent B cell lymphoma and is still considered to be incurable. In recent years, whole-exome sequencing studies of large cohorts of patients have greatly improved our knowledge of the FL mutational landscape. Moreover, the prolonged evolution of this (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Sarah Huet Pierre Sujobert Gilles Salles Tags: Review Source Type: research
Genetic insights into the morass of metastatic heterogeneity
Nature Reviews Cancer 18, 211 (2018).
doi:10.1038/nrc.2017.126
Authors: Kent W. Hunter, Ruhul Amin, Sarah Deasy, Ngoc-Han Ha & Lalage Wakefield
Tumour heterogeneity poses a substantial problem for the clinical management of cancer. Somatic evolution of the cancer genome results in genetically distinct subclones in the primary tumour with different biological properties and therapeutic sensitivities. The problem of heterogeneity is compounded in metastatic disease owing to (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Kent W. Hunter Ruhul Amin Sarah Deasy Ngoc-Han Ha Lalage Wakefield Tags: Review Source Type: research
Immunotherapy: Viral reprogramming
Nature Reviews Cancer 18, 135 (2018).
doi:10.1038/nrc.2018.12
Author: Anna Dart
Two studies have shown that oncolytic virus treatment prior to surgery can prime the tumour immune microenvironment for subsequent immune checkpoint inhibition and lead to better outcomes in preclinical models of breast and brain cancers. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Targeting minimal residual disease: a path to cure?
Nature Reviews Cancer 18, 255 (2018).
doi:10.1038/nrc.2017.125
Authors: Marlise R. Luskin, Mark A. Murakami, Scott R. Manalis & David M. Weinstock
Therapeutics that block kinases, transcriptional modifiers, immune checkpoints and other biological vulnerabilities are transforming cancer treatment. As a result, many patients achieve dramatic responses, including complete radiographical or pathological remission, yet retain minimal residual disease (MRD), which results in relapse. New functional approaches can characterize (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 29, 2018 Category: Cancer & Oncology Authors: Marlise R. Luskin Mark A. Murakami Scott R. Manalis David M. Weinstock Tags: Perspectives Source Type: research
Tumour budding in colorectal cancer: molecular rationale for clinical translation
Nature Reviews Cancer 18, 203 (2018).
doi:10.1038/nrc.2018.1
Authors: Inti Zlobec & Alessandro Lugli
Precision medicine and personalized health care call for reproducible and standardized predictive and prognostic biomarkers that can influence the clinical management of patients with cancer. In colorectal cancer, tumour budding — a histological manifestation of tumour cell invasion that is likened to epithelial–mesenchymal transition — is now emerging as one such factor. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 29, 2018 Category: Cancer & Oncology Authors: Inti Zlobec Alessandro Lugli Tags: Comment Source Type: research
Fanconi anaemia and cancer: an intricate relationship
Nature Reviews Cancer 18, 168 (2018).
doi:10.1038/nrc.2017.116
Authors: Grzegorz Nalepa & D. Wade Clapp
Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure (BMF), developmental abnormalities and predisposition to cancer. Together with other proteins involved in DNA repair processes and cell division, the FA proteins maintain genome homeostasis, and germline mutation of any one (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 29, 2018 Category: Cancer & Oncology Authors: Grzegorz Nalepa D. Wade Clapp Tags: Review Source Type: research
Corrigendum: Ribosome biogenesis in cancer: new players and therapeutic avenues
Nature Reviews Cancer 18, 134 (2018).
doi:10.1038/nrc.2018.3
Author: Joffrey Pelletier, George Thomas & Siniša Volarević
Nature Reviews Cancer18, 51–63 (2018)In this article a source of grant funding for one of the authors was omitted from the Acknowledgements section. The online version of the article has been corrected to include: “The work of (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 25, 2018 Category: Cancer & Oncology Authors: Joffrey Pelletier George Thomas Sini š a Volarevi ć Tags: Corrigendum Source Type: research
Oncogenes: Driving immune evasion
Nature Reviews Cancer 18, 67 (2018).
doi:10.1038/nrc.2018.5
Author: Sarah Seton-Rogers
Three recent papers have shed light on how the common oncogenic drivers MYC and RAS can induce an immunosuppressive tumour microenvironment. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - January 25, 2018 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
