Leukaemia: Unravelling the heterogeneity of cancer stem cells
Nature Reviews Cancer 17, 397 (2017).
doi:10.1038/nrc.2017.44
Author: Sarah Seton-Rogers
Giustacchini, Thongjuea, et al. have developed a method to sensitively detect somatic mutations and analyze whole transcriptomes of the same single cell. Application of this technique to chronic myeloid leukaemia (CML) patient samples revealed heterogeneous CML stem cell populations with likely roles in CML progression and resistance to therapy. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - June 9, 2017 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Cancer models: Tailored mouse models
Nature Reviews Cancer 17, 395 (2017).
doi:10.1038/nrc.2017.45
Author: Anna Dart
To advance preclinical research, two groups have developed mouse models of metastatic colorectal cancer using the transplantation of engineered organoids. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - June 9, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Immunotherapy: Programming T cells in situ
Nature Reviews Cancer 17, 372 (2017).
doi:10.1038/nrc.2017.38
Author: Sarah Seton-Rogers
Adoptive T cell therapy with patient-derived cells engineered ex vivo to express chimeric antigen receptors (CARs) is a promising therapeutic strategy in cancer, but producing these cells for a large number of patients is both technically challenging and cost prohibitive. Smith et al. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - May 24, 2017 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Genetics: Gender-specific factors in cancer susceptibility
Nature Reviews Cancer 17, 372 (2017).
doi:10.1038/nrc.2017.37
Author: Sarah Seton-Rogers
Two studies published in Nature Genetics have delved into the complex genetics of cancer susceptibility and have shown links of both timing of puberty onset and mosaic loss of chromosome Y (mLOY) to cancer risk.Previous genomic analyses have indicated various genetic factors associated (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - May 24, 2017 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
Nature Reviews Cancer 17, 352 (2017).
doi:10.1038/nrc.2017.28
Authors: Silvia von Karstedt, Antonella Montinaro & Henning Walczak
The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study of pro-apoptotic TRAIL receptor (TRAIL-R) signalling and the development of biotherapeutic drug candidates that activate TRAIL-Rs. The outcome (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - May 24, 2017 Category: Cancer & Oncology Authors: Silvia von Karstedt Antonella Montinaro Henning Walczak Tags: Review Source Type: research
Immunotherapy: T cells get a ride
Nature Reviews Cancer 17, 333 (2017).
doi:10.1038/nrc.2017.39
Author: M. Teresa Villanueva
Strategies that inhibit the immune checkpoint blockade (ICB) and reactivate T cells using monoclonal antibodies against programmed cell death protein 1 (PD1) and PD1 ligand 1 (PDL1) have been used to successfully treat immunogenic tumours, and recent efforts have focused on combining this approach with (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - May 24, 2017 Category: Cancer & Oncology Authors: M. Teresa Villanueva Tags: Research Highlight Source Type: research
Common pitfalls in preclinical cancer target validation
Nature Reviews Cancer 17, 425 (2017).
doi:10.1038/nrc.2017.32
Author: William G. Kaelin
An alarming number of papers from laboratories nominating new cancer drug targets contain findings that cannot be reproduced by others or are simply not robust enough to justify drug discovery efforts. This problem probably has many causes, including an underappreciation of the danger of being (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - May 19, 2017 Category: Cancer & Oncology Authors: William G. Kaelin Tags: Perspectives Source Type: research
Metastasis: The plastic state
Nature Reviews Cancer 17, 373 (2017).
doi:10.1038/nrc.2017.34
Author: Anna Dart
ZEB1-mediated epithelial-mesenchymal transition (EMT) and cellular plasticity promotes metastasis in pancreatic cancer. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - May 12, 2017 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research
Tumorigenesis: Cancer as a symptom of evolution?
Nature Reviews Cancer 17, 373 (2017).
doi:10.1038/nrc.2017.33
Author: Gemma K. Alderton
A paper in Science by Tomasetti, Li and Vogelstein develops their 'bad luck' model further and explores how different sources of DNA mutation influence different cancer types. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - May 5, 2017 Category: Cancer & Oncology Authors: Gemma K. Alderton Tags: Research Highlight Source Type: research
Melanoma: a global perspective
Nature Reviews Cancer 17, 393 (2017).
doi:10.1038/nrc.2017.43
Authors: Raul Ossio, Rodrigo Roldán-Marín, Héctor Martínez-Said, David J. Adams & Carla Daniela Robles-Espinoza
Most of our current knowledge of melanoma is derived from the study of patients from populations of European descent, for whom public health, sun protection initiatives and screening measures have appreciably decreased disease mortality. Notably, some melanoma subtypes that most commonly develop in other populations (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 28, 2017 Category: Cancer & Oncology Authors: Raul Ossio Rodrigo Rold á n-Mar í n H é ctor Mart í nez-Said David J. Adams Carla Daniela Robles-Espinoza Tags: Comment Source Type: research
The ETS family of oncogenic transcription factors in solid tumours
Nature Reviews Cancer 17, 337 (2017).
doi:10.1038/nrc.2017.20
Authors: Gina M. Sizemore, Jason R. Pitarresi, Subhasree Balakrishnan & Michael C. Ostrowski
Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene rearrangement and amplification, feed-forward growth factor signalling loops, formation of gain-of-function co-regulatory complexes and novel cis-acting mutations in ETS (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 28, 2017 Category: Cancer & Oncology Authors: Gina M. Sizemore Jason R. Pitarresi Subhasree Balakrishnan Michael C. Ostrowski Tags: Review Source Type: research
Leukaemia: 'Gimme shelter'
Nature Reviews Cancer 17, 332 (2017).
doi:10.1038/nrc.2017.14
Author: Nicola McCarthy
Leukaemia (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 24, 2017 Category: Cancer & Oncology Authors: Nicola McCarthy Tags: Correction Source Type: research
New frontiers in translational control of the cancer genome
Nature Reviews Cancer 17, 332 (2017).
doi:10.1038/nrc.2017.30
Author: Morgan L. Truitt & Davide Ruggero
Nature Reviews Cancer16, 288–30410.1038/nrc.2016.27 (2016)In this Review, in Figure 1, for both the figure and figure legend 'eIF4B' was incorrectly labelled as 'eIF2B'. The paper has been corrected online. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 24, 2017 Category: Cancer & Oncology Authors: Morgan L. Truitt Davide Ruggero Tags: Corrigendum Source Type: research
Tumour Suppressors: Following the clues of cancer-resistant tissues
Nature Reviews Cancer 17, 269 (2017).
doi:10.1038/nrc.2017.29
Author: Sarah Seton-Rogers
Using gene expression analyses of cancer-resistant differentiated muscle cells, Keckesova et al. identify a mitochondrial protein, lactamase β (LACTB), that affects lipid metabolism and can induce differentiation and suppress proliferation of breast cancer cells in vitro and in vivo. (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 24, 2017 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research
Leukaemia: 'Gimme shelter'
Nature Reviews Cancer 17, 332 (2017).
doi:10.1038/nrc.2017.14
Author: Nicola McCarthy
Leukaemia (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - April 24, 2017 Category: Cancer & Oncology Authors: Nicola McCarthy Tags: Correction Source Type: research
