Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy

Nature Reviews Cancer 17, 352 (2017). doi:10.1038/nrc.2017.28 Authors: Silvia von Karstedt, Antonella Montinaro & Henning Walczak The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study of pro-apoptotic TRAIL receptor (TRAIL-R) signalling and the development of biotherapeutic drug candidates that activate TRAIL-Rs. The outcome
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research