The ETS family of oncogenic transcription factors in solid tumours

Nature Reviews Cancer 17, 337 (2017). doi:10.1038/nrc.2017.20 Authors: Gina M. Sizemore, Jason R. Pitarresi, Subhasree Balakrishnan & Michael C. Ostrowski Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene rearrangement and amplification, feed-forward growth factor signalling loops, formation of gain-of-function co-regulatory complexes and novel cis-acting mutations in ETS
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research