Genetic insights into the morass of metastatic heterogeneity
Nature Reviews Cancer 18, 211 (2018).
doi:10.1038/nrc.2017.126
Authors: Kent W. Hunter, Ruhul Amin, Sarah Deasy, Ngoc-Han Ha & Lalage Wakefield
Tumour heterogeneity poses a substantial problem for the clinical management of cancer. Somatic evolution of the cancer genome results in genetically distinct subclones in the primary tumour with different biological properties and therapeutic sensitivities. The problem of heterogeneity is compounded in metastatic disease owing to
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Kent W. Hunter Ruhul Amin Sarah Deasy Ngoc-Han Ha Lalage Wakefield Tags: Review Source Type: research