Genetic insights into the morass of metastatic heterogeneity

Nature Reviews Cancer 18, 211 (2018). doi:10.1038/nrc.2017.126 Authors: Kent W. Hunter, Ruhul Amin, Sarah Deasy, Ngoc-Han Ha & Lalage Wakefield Tumour heterogeneity poses a substantial problem for the clinical management of cancer. Somatic evolution of the cancer genome results in genetically distinct subclones in the primary tumour with different biological properties and therapeutic sensitivities. The problem of heterogeneity is compounded in metastatic disease owing to
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research