A chemical probe toolbox for dissecting the cancer epigenome

Nature Reviews Cancer 17, 160 (2017). doi:10.1038/nrc.2016.148 Authors: Jake Shortt, Christopher J. Ott, Ricky W. Johnstone & James E. Bradner Cancer cell hallmarks are underpinned by transcriptional programmes operating in the context of a dynamic and complicit epigenomic environment. Somatic alterations of chromatin modifiers are among the most prevalent cancer perturbations. There is a pressing need for targeted chemical probes to dissect these complex, interconnected
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research