Tumour suppressors: Digging deeper into p53's functions

Nature Reviews Cancer 17, 706 (2017). doi:10.1038/nrc.2017.108 Author: Sarah Seton-Rogers Mello et al. analysed the effects of various p53 transactivation domain mutants in pancreatic ductal adenocarcinoma and uncovered a crucial tumour-suppressive pathway in which p53 mediates inhibition of the transcriptional co-activator YAP.
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research