Tumour suppressors: Digging deeper into p53's functions
Nature Reviews Cancer 17, 706 (2017).
doi:10.1038/nrc.2017.108
Author: Sarah Seton-Rogers
Mello et al. analysed the effects of various p53 transactivation domain mutants in pancreatic ductal adenocarcinoma and uncovered a crucial tumour-suppressive pathway in which p53 mediates inhibition of the transcriptional co-activator YAP.
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: research