Advances and challenges in targeting FGFR signalling in cancer

Nature Reviews Cancer 17, 318 (2017). doi:10.1038/nrc.2017.8 Authors: Irina S. Babina & Nicholas C. Turner Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research