Pre-metastatic niches: organ-specific homes for metastases

Nature Reviews Cancer 17, 302 (2017). doi:10.1038/nrc.2017.6 Authors: Héctor Peinado, Haiying Zhang, Irina R. Matei, Bruno Costa-Silva, Ayuko Hoshino, Goncalo Rodrigues, Bethan Psaila, Rosandra N. Kaplan, Jacqueline F. Bromberg, Yibin Kang, Mina J. Bissell, Thomas R. Cox, Amato J. Giaccia, Janine T. Erler, Sachie Hiratsuka, Cyrus M. Ghajar & David Lyden It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research