Tumour metabolism: When metabolic and epigenetic states converge

Nature Reviews Cancer 16, 757 (2016). doi:10.1038/nrc.2016.134 Author: Anna Dart Metabolic and epigenetic states in cells can be linked when intermediary metabolism generates substrates for chromatin regulation. Kottakis et al. have found that synergistic liver kinase B1 (LKB1) loss and KRAS activation can promote mTOR-mediated serine biosynthesis pathway dependency during pancreatic tumorigenesis. The subsequent

http://feeds.nature.com/~r/nrc/rss/current/~3/oFwVfBGFRcU/nrc.2016.134

Source: Nature Reviews Cancer - November 22, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research