SUMO and the robustness of cancer

Nature Reviews Cancer 17, 184 (2017). doi:10.1038/nrc.2016.143 Authors: Jacob-Sebastian Seeler & Anne Dejean Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed sumoylation, is an important mechanism in cellular responses to stress and one that appears to be upregulated in many cancers. Here, we examine the role of sumoylation in tumorigenesis as a possibly necessary safeguard that protects
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research