Tumour metabolism: Lactic acid: not just a waste product?

Nature Reviews Cancer 16, 676 (2016). doi:10.1038/nrc.2016.109 Author: Anna Dart Brand and colleagues show that increased tumour lactate dehydrogenase A (LDHA)-mediated lactic acid production dampens activation and cytokine production of infiltrating T and natural killer (NK) cells allowing tumours to escape immune detection and promoting tumour growth.

http://feeds.nature.com/~r/nrc/rss/current/~3/XFXKWkPRTUE/nrc.2016.109

Source: Nature Reviews Cancer - October 6, 2016 Category: Cancer & Oncology Authors: Anna Dart Tags: Research Highlight Source Type: research

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