Oxygen availability and metabolic adaptations
Nature Reviews Cancer 16, 663 (2016).
doi:10.1038/nrc.2016.84
Authors: Michael S. Nakazawa, Brian Keith & M. Celeste Simon
Oxygen availability, along with the abundance of nutrients (such as glucose, glutamine, lipids and albumin), fluctuates significantly during tumour evolution and the recruitment of blood vessels, leukocytes and reactive fibroblasts to complex tumour microenvironments. As such, hypoxia and concomitant nutrient scarcity affect large gene expression
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Michael S. Nakazawa Brian Keith M. Celeste Simon Tags: Review Source Type: research