Oxygen availability and metabolic adaptations

Nature Reviews Cancer 16, 663 (2016). doi:10.1038/nrc.2016.84 Authors: Michael S. Nakazawa, Brian Keith & M. Celeste Simon Oxygen availability, along with the abundance of nutrients (such as glucose, glutamine, lipids and albumin), fluctuates significantly during tumour evolution and the recruitment of blood vessels, leukocytes and reactive fibroblasts to complex tumour microenvironments. As such, hypoxia and concomitant nutrient scarcity affect large gene expression
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research