Tumour metabolism: Functions of fumarate

Nature Reviews Cancer 16, 617 (2016). doi:10.1038/nrc.2016.102 Author: Sarah Seton-Rogers Sciacovelli et al. find that the higher levels of intracellular fumarate that result from loss of fumarate hydratase (FH), which causes hereditary leiomyomatosis and renal cell carcinoma (HLRCC), promotes epithelial-to-mesenchymal transition (EMT). Fumarate inhibits tet methylcytosine dioxygenase (TET) family enzymes, and the
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research