The role of enhancers in cancer

Nature Reviews Cancer 16, 483 (2016). doi:10.1038/nrc.2016.62 Authors: Inderpreet Sur & Jussi Taipale Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their most important functions is the integration of extracellular signals with intracellular cell fate information to generate cell type-specific transcriptional responses. Mutations occurring in cancer often misregulate enhancers that normally control
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research