Tumour metabolism: Location matters

Nature Reviews Cancer 16, 678 (2016). doi:10.1038/nrc.2016.117 Author: Anna Dart Glutamine is heavily consumed by tumours. Yet, the regional effects of glutamine deprivation within tumours are unknown. Pan et al. show that low glutamine in the tumour core results in increased histone hypermethylation through a decrease inα-ketoglutarate levels. Depleted glutamine-mediated histone hypermethylation causes cellular
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research