Gap junctions and cancer: communicating for 50 years

Nature Reviews Cancer 16, 775 (2016). doi:10.1038/nrc.2016.105 Authors: Trond Aasen, Marc Mesnil, Christian C. Naus, Paul D. Lampe & Dale W. Laird Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis that loss of direct intercellular communication is commonly associated with cancer onset and progression. Subsequent studies linked this phenomenon to gap junctions composed of connexin proteins. Although many studies support
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Perspectives Source Type: research