Metabolic control of epigenetics in cancer

Nature Reviews Cancer 16, 694 (2016). doi:10.1038/nrc.2016.82 Authors: Adam Kinnaird, Steven Zhao, Kathryn E. Wellen & Evangelos D. Michelakis Alterations in the epigenome and metabolism both affect molecular rewiring in cancer cells and facilitate cancer development and progression. However, recent evidence suggests the existence of important bidirectional regulatory mechanisms between metabolic remodelling and the epigenome (specifically methylation and acetylation of histones) in cancer. Most
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research