Serine and one-carbon metabolism in cancer

Nature Reviews Cancer 16, 650 (2016). doi:10.1038/nrc.2016.81 Authors: Ming Yang & Karen H. Vousden The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research